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Amer2 APC membrane recruitment 2 [ Mus musculus (house mouse) ]

Gene ID: 72125, updated on 2-Nov-2024

Summary

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Official Symbol
Amer2provided by MGI
Official Full Name
APC membrane recruitment 2provided by MGI
Primary source
MGI:MGI:1919375
See related
Ensembl:ENSMUSG00000021986 AllianceGenome:MGI:1919375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam123a; 2600011E07Rik
Summary
Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in ectoderm development and negative regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human AMER2 (APC membrane recruitment protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 8.0), whole brain E14.5 (RPKM 7.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Amer2 in Genome Data Viewer
Location:
14 D1; 14 31.62 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60615141..60625642)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60373288..60388197)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60870359-60870542 Neighboring gene nucleoporin 58 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60883833-60884016 Neighboring gene myotubularin related protein 6 Neighboring gene STARR-seq mESC enhancer starr_36856 Neighboring gene STARR-seq mESC enhancer starr_36857 Neighboring gene predicted gene, 34874 Neighboring gene peptidylprolyl isomerase A pseudogene 14_696.1 Neighboring gene spermatogenesis associated 13 Neighboring gene STARR-positive B cell enhancer ABC_E11785 Neighboring gene VISTA enhancer mm1122 Neighboring gene predicted gene, 41166

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression patterns of the Wtx/Amer gene family during mouse embryonic development. Comai G, et al. Dev Dyn, 2010 Jun. PMID 20503382
  2. Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. Pfister AS, et al. J Biol Chem, 2012 Oct 12. PMID 22898821, Free PMC Article
  3. Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry. Del Mar Masdeu M, et al. Oncotarget, 2017 Nov 24. PMID 29254152, Free PMC Article
  4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.
    Title: Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ectoderm development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
APC membrane recruitment protein 2
Names
family with sequence similarity 123, member A
protein FAM123A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164705.2 → NP_001158177.2  APC membrane recruitment protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166113
    Consensus CDS
    CCDS88682.1
    UniProtKB/TrEMBL
    A0A0R4J030
    Related
    ENSMUSP00000153031.3, ENSMUST00000225247.3
    Conserved Domains (1) summary
    pfam09422
    Location:94 → 463
    WTX; WTX protein

  2. NM_001368677.1 → NP_001355606.1  APC membrane recruitment protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166113
    UniProtKB/TrEMBL
    A0A0R4J030
    Conserved Domains (1) summary
    pfam09422
    Location:94 → 532
    WTX; WTX protein

  3. NM_028113.4 → NP_082389.2  APC membrane recruitment protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166113
    Consensus CDS
    CCDS27177.2
    UniProtKB/Swiss-Prot
    Q7TNC5, Q8CCJ4, Q8K0U9, Q9D0Q2
    UniProtKB/TrEMBL
    A0A0R4J030
    Related
    ENSMUSP00000022561.8, ENSMUST00000022561.9
    Conserved Domains (1) summary
    pfam09422
    Location:94 → 589
    WTX; WTX protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    60615141..60625642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCJ4.2 GenPept UniProtKB/Swiss-Prot:Q8CCJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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