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Phf10 PHD finger protein 10 [ Mus musculus (house mouse) ]

Gene ID: 72057, updated on 11-Apr-2024

Summary

Official Symbol
Phf10provided by MGI
Official Full Name
PHD finger protein 10provided by MGI
Primary source
MGI:MGI:1919307
See related
Ensembl:ENSMUSG00000023883 AllianceGenome:MGI:1919307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810055P05Rik
Summary
Predicted to enable histone binding activity and transcription coregulator activity. Involved in nervous system development. Part of npBAF complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and tooth. Orthologous to human PHF10 (PHD finger protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 29.8), liver E14.5 (RPKM 23.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
17 8.95 cM; 17 A2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (15165269..15181550, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (14944994..14961260, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_41895 Neighboring gene predicted gene, 23352 Neighboring gene WD repeat domain 27 Neighboring gene STARR-seq mESC enhancer starr_41897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:15046536-15046719 Neighboring gene RIKEN cDNA 1600012H06 gene Neighboring gene STARR-positive B cell enhancer ABC_E9166 Neighboring gene dynein light chain Tctex-type 2A3 Neighboring gene STARR-seq mESC enhancer starr_41898 Neighboring gene ER membrane associated RNA degradation like 2 Neighboring gene predicted gene 3255

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of RSC-type complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
part_of npBAF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of npBAF complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear matrix NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
PHD finger protein 10
Names
BAF45a
BRG1-associated factor 45a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360983.2NP_001347912.1  PHD finger protein 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC182749
  2. NM_024250.5NP_077212.3  PHD finger protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC182749
    Consensus CDS
    CCDS28407.2
    UniProtKB/Swiss-Prot
    E9QLI2, Q99LV5, Q9D8M7
    UniProtKB/TrEMBL
    K4DI61
    Related
    ENSMUSP00000024657.6, ENSMUST00000024657.12
    Conserved Domains (2) summary
    cd15528
    Location:379432
    PHD1_PHF10; PHD finger 1 found in PHD finger protein 10 (PHF10) and similar proteins
    cd15529
    Location:434477
    PHD2_PHF10; PHD finger 2 found in PHD finger protein 10 (PHF10) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    15165269..15181550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)