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Dnmbp dynamin binding protein [ Mus musculus (house mouse) ]

Gene ID: 71972, updated on 2-Nov-2024

Summary

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Official Symbol
Dnmbpprovided by MGI
Official Full Name
dynamin binding proteinprovided by MGI
Primary source
MGI:MGI:1917352
See related
Ensembl:ENSMUSG00000025195 AllianceGenome:MGI:1917352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TUBA; 2410003L07Rik; 2410003M15Rik
Summary
This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in colon adult (RPKM 15.1), large intestine adult (RPKM 10.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Dnmbp in Genome Data Viewer
Location:
19 C3; 19 36.67 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43835259..43930930, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43846815..43940232, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family member 2 Neighboring gene STARR-seq mESC enhancer starr_46204 Neighboring gene predicted gene 10768 Neighboring gene predicted gene, 24400 Neighboring gene STARR-seq mESC enhancer starr_46211 Neighboring gene RIKEN cDNA 4933403J19 gene Neighboring gene carboxypeptidase N, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of protrusion formation during cell-to-cell spread of Listeria. Ireton K, et al. Front Cell Infect Microbiol, 2014. PMID 24600591, Free PMC Article
  2. The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Rajabian T, et al. Nat Cell Biol, 2009 Oct. PMID 19767742, Free PMC Article
  3. Impact of the Listeria monocytogenes protein InlC on infection in mice. Leung N, et al. Infect Immun, 2013 Apr. PMID 23403554, Free PMC Article
  4. Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42. Oda Y, et al. J Cell Sci, 2014 Oct 1. PMID 25097232
  5. Tuba stimulates intracellular N-WASP-dependent actin assembly. Kovacs EM, et al. J Cell Sci, 2006 Jul 1. PMID 16757518

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynamin-binding protein
Names
scaffold protein Tuba

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306088.2 → NP_001293017.1  dynamin-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001293017.1

    Status: VALIDATED

    Source sequence(s)
    AC132251
    Consensus CDS
    CCDS84442.1
    UniProtKB/TrEMBL
    A0A1D5RLL6
    Related
    ENSMUSP00000148421.2, ENSMUST00000212592.2
    Conserved Domains (4) summary
    cd07589
    Location:263 → 454
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11798
    Location:535 → 591
    SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
    cd12141
    Location:763 → 819
    SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
    cd00160
    Location:31 → 211
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

  2. NM_001403290.1 → NP_001390219.1  dynamin-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132251
    UniProtKB/TrEMBL
    A0A1D5RMB5
    Related
    ENSMUSP00000148708.2, ENSMUST00000212032.2

  3. NM_001403291.1 → NP_001390220.1  dynamin-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132251
    UniProtKB/TrEMBL
    A0A1D5RMB5

  4. NM_001403292.1 → NP_001390221.1  dynamin-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132251

  5. NM_001403293.1 → NP_001390222.1  dynamin-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132251

  6. NM_001403294.1 → NP_001390223.1  dynamin-binding protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC132251

  7. NM_001403295.1 → NP_001390224.1  dynamin-binding protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC132251
    Related
    ENSMUSP00000148546.2, ENSMUST00000212048.2

  8. NM_001403296.1 → NP_001390225.1  dynamin-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132251
    UniProtKB/TrEMBL
    A0A1D5RLL6

  9. NM_001403297.1 → NP_001390226.1  dynamin-binding protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC132251

  10. NM_028029.5 → NP_082305.1  dynamin-binding protein isoform 1

    See identical proteins and their annotated locations for NP_082305.1

    Status: VALIDATED

    Source sequence(s)
    AC132251
    Consensus CDS
    CCDS29839.1
    UniProtKB/Swiss-Prot
    Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2
    UniProtKB/TrEMBL
    A0A0R4J055
    Related
    ENSMUSP00000148582.2, ENSMUST00000212396.2
    Conserved Domains (8) summary
    cd07589
    Location:1020 → 1211
    BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
    cd11794
    Location:7 → 56
    SH3_DNMBP_N1; First N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
    cd11795
    Location:70 → 124
    SH3_DNMBP_N2; Second N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
    cd11796
    Location:150 → 200
    SH3_DNMBP_N3; Third N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
    cd11798
    Location:1292 → 1348
    SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
    cd12141
    Location:1520 → 1576
    SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
    pfam00621
    Location:787 → 969
    RhoGEF; RhoGEF domain
    cl17036
    Location:248 → 297
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43835259..43930930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TXD4.2 GenPept UniProtKB/Swiss-Prot:Q6TXD4

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