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Cers5 ceramide synthase 5 [ Mus musculus (house mouse) ]

Gene ID: 71949, updated on 12-May-2024

Summary

Official Symbol
Cers5provided by MGI
Official Full Name
ceramide synthase 5provided by MGI
Primary source
MGI:MGI:1919199
See related
Ensembl:ENSMUSG00000023021 AllianceGenome:MGI:1919199
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trh4; Lass5; 2310081H14Rik
Summary
Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Acts upstream of or within sphingolipid biosynthetic process. Located in endoplasmic reticulum. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut. Orthologous to human CERS5 (ceramide synthase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 25.1), CNS E18 (RPKM 20.0) and 27 other tissues See more
Orthologs
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Genomic context

See Cers5 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99633473..99670396, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99735592..99772515, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99555871-99556054 Neighboring gene predicted gene 16537 Neighboring gene glycerol-3-phosphate dehydrogenase 1 (soluble) Neighboring gene cytochrome c oxidase assembly protein 14 Neighboring gene LIM domain and actin binding 1 Neighboring gene VISTA enhancer mm17 Neighboring gene predicted gene, 25897 Neighboring gene 60S ribosomal protein L37 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingosine N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingosine N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ceramide synthase 5
Names
LAG1 homolog, ceramide synthase 5
LAG1 longevity assurance homolog 5
TRAM homolog 4
longevity assurance homolog 5
sphingoid base N-palmitoyltransferase CERS5
sphingosine N-acyltransferase CERS5
translocating chain-associating membrane protein homolog 4
NP_082291.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028015.2NP_082291.1  ceramide synthase 5

    See identical proteins and their annotated locations for NP_082291.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046797
    Consensus CDS
    CCDS27830.1
    UniProtKB/Swiss-Prot
    Q3UL17, Q80YB2, Q8BPH6, Q921T8, Q924Z3, Q9D6K9
    Related
    ENSMUSP00000023762.7, ENSMUST00000023762.13
    Conserved Domains (2) summary
    smart00724
    Location:139340
    TLC; TRAM, LAG1 and CLN8 homology domains
    cd00086
    Location:87136
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99633473..99670396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)