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Epn3 epsin 3 [ Mus musculus (house mouse) ]

Gene ID: 71889, updated on 2-Nov-2024

Summary

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Official Symbol
Epn3provided by MGI
Official Full Name
epsin 3provided by MGI
Primary source
MGI:MGI:1919139
See related
Ensembl:ENSMUSG00000010080 AllianceGenome:MGI:1919139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310022G12Rik
Summary
Enables EH domain binding activity. Predicted to be involved in endocytosis. Located in clathrin-coated pit. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and respiratory system. Orthologous to human EPN3 (epsin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in stomach adult (RPKM 51.8), lung adult (RPKM 22.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Epn3 in Genome Data Viewer
Location:
11 D; 11 58.9 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94380425..94390800, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94489599..94499974, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, T type, alpha 1G subunit Neighboring gene predicted gene, 51872 Neighboring gene STARR-seq mESC enhancer starr_30468 Neighboring gene STARR-positive B cell enhancer ABC_E10707 Neighboring gene spermatogenesis associated 20 Neighboring gene predicted gene, 51873 Neighboring gene MYCBP associated protein Neighboring gene predicted gene, 35650 Neighboring gene radical S-adenosyl methionine domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis. Mori J, et al. Neoplasia, 2017 Mar. PMID 28152424, Free PMC Article
  2. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Messa M, et al. Elife, 2014 Aug 13. PMID 25122462, Free PMC Article
  3. Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi. Ko G, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21115825, Free PMC Article
  4. T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system. Mohan RA, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32675240, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
    Title: Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
  2. data suggest that epsin 3 cooperates with other bilayer binding proteins with curvature sensing/generating properties in the specialized traffic and membrane remodeling processes typical of gastric parietal cells
    Title: Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables EH domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epsin-3
Names
EPS-15-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361558.1 → NP_001348487.1  epsin-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL645809
    UniProtKB/TrEMBL
    Q3TZ84
    Conserved Domains (3) summary
    smart00726
    Location:202 → 221
    UIM; Ubiquitin-interacting motif
    cd03571
    Location:19 → 141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl26464
    Location:275 → 607
    Atrophin-1; Atrophin-1 family

  2. NM_027984.3 → NP_082260.1  epsin-3 isoform 1

    See identical proteins and their annotated locations for NP_082260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK009469, AL645809
    Consensus CDS
    CCDS25257.1
    UniProtKB/Swiss-Prot
    Q91W69, Q9CV55
    UniProtKB/TrEMBL
    Q3TZ84
    Related
    ENSMUSP00000121390.2, ENSMUST00000127305.2
    Conserved Domains (3) summary
    smart00726
    Location:202 → 221
    UIM; Ubiquitin-interacting motif
    PHA03247
    Location:302 → 634
    PHA03247; large tegument protein UL36; Provisional
    cd16990
    Location:19 → 142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    94380425..94390800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534266.4 → XP_006534329.1  epsin-3 isoform X1

    See identical proteins and their annotated locations for XP_006534329.1

    UniProtKB/Swiss-Prot
    Q91W69, Q9CV55
    UniProtKB/TrEMBL
    Q3TZ84
    Conserved Domains (3) summary
    smart00726
    Location:202 → 221
    UIM; Ubiquitin-interacting motif
    PHA03247
    Location:302 → 634
    PHA03247; large tegument protein UL36; Provisional
    cd16990
    Location:19 → 142
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91W69.1 GenPept UniProtKB/Swiss-Prot:Q91W69

Gene LinkOut

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