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R3hcc1 R3H domain and coiled-coil containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71843, updated on 2-Nov-2024

Summary

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Official Symbol
R3hcc1provided by MGI
Official Full Name
R3H domain and coiled-coil containing 1provided by MGI
Primary source
MGI:MGI:1919093
See related
Ensembl:ENSMUSG00000034194 AllianceGenome:MGI:1919093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700020M16Rik
Summary
Predicted to enable nucleic acid binding activity. Orthologous to human R3HCC1 (R3H domain and coiled-coil containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 28.9), testis adult (RPKM 28.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See R3hcc1 in Genome Data Viewer
Location:
14 D2; 14 36.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69934753..69952258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69697304..69714809, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 4B Neighboring gene predicted gene 27177 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69994605-69994905 Neighboring gene lysyl oxidase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70029225-70029526 Neighboring gene microRNA 6950 Neighboring gene STARR-positive B cell enhancer ABC_E4117 Neighboring gene RIKEN cDNA 4930480K23 gene Neighboring gene STARR-positive B cell enhancer ABC_E1900 Neighboring gene charged multivesicular body protein 7 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene PR domain containing 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Lee S, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927429, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ribosome profiling indicates that this gene can use a non-AUG (CUG) start codon in both human HEK293 and mouse embryonic fibroblast cells.
    Title: Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
R3H and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146012.2 → NP_001139484.2  R3H and coiled-coil domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001139484.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    AC160639, AK032854, BQ747890
    Consensus CDS
    CCDS49533.2
    UniProtKB/Swiss-Prot
    Q8BSI6
    UniProtKB/TrEMBL
    E9PUE1
    Related
    ENSMUSP00000113450.3, ENSMUST00000118374.8
    Conserved Domains (2) summary
    cd02638
    Location:19 → 79
    R3H_unknown_1; R3H domain of a group of eukaryotic proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in ...
    cl17169
    Location:365 → 429
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001301651.1 → NP_001288580.1  R3H and coiled-coil domain-containing protein 1 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC160639, AK006177, BQ747890
    UniProtKB/TrEMBL
    E9PUE1
    Conserved Domains (2) summary
    cd02638
    Location:33 → 93
    R3H_unknown_1; R3H domain of a group of eukaryotic proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in ...
    cl17169
    Location:379 → 443
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001301652.1 → NP_001288581.1  R3H and coiled-coil domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001288581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
    Source sequence(s)
    BC059860, BQ747890
    Consensus CDS
    CCDS49533.2
    UniProtKB/Swiss-Prot
    Q8BSI6
    UniProtKB/TrEMBL
    E9PUE1
    Related
    ENSMUSP00000113898.3, ENSMUST00000121142.4
    Conserved Domains (2) summary
    cd02638
    Location:19 → 79
    R3H_unknown_1; R3H domain of a group of eukaryotic proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in ...
    cl17169
    Location:365 → 429
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    69934753..69952258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSI6.3 GenPept UniProtKB/Swiss-Prot:Q8BSI6

Gene LinkOut

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