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Dync2i2 dynein 2 intermediate chain 2 [ Mus musculus (house mouse) ]

Gene ID: 71820, updated on 21-Apr-2024

Summary

Official Symbol
Dync2i2provided by MGI
Official Full Name
dynein 2 intermediate chain 2provided by MGI
Primary source
MGI:MGI:1919070
See related
Ensembl:ENSMUSG00000039715 AllianceGenome:MGI:1919070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr34; 3200002I06Rik
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cilium assembly and intraciliary retrograde transport. Located in cytoskeleton and filopodium. Part of cytoplasmic dynein complex. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 29.0), testis adult (RPKM 27.5) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 B; 2 21.04 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29921563..29938891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30031551..30048879, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4425 Neighboring gene GLE1 RNA export mediator Neighboring gene STARR-seq mESC enhancer starr_04079 Neighboring gene STARR-seq mESC enhancer starr_04080 Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene SET nuclear oncogene Neighboring gene protein kinase N3 Neighboring gene zinc finger, DHHC domain containing 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103259

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein light chain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary retrograde transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in ciliary plasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytoplasmic dynein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 2 intermediate chain 2
Names
WD repeat domain 34
WD repeat-containing protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008498.2NP_001008498.2  cytoplasmic dynein 2 intermediate chain 2

    See identical proteins and their annotated locations for NP_001008498.2

    Status: VALIDATED

    Source sequence(s)
    BC085113, BX005298
    Consensus CDS
    CCDS15865.2
    UniProtKB/Swiss-Prot
    A2BE91, Q5U4F6
    Related
    ENSMUSP00000109340.3, ENSMUST00000113711.3
    Conserved Domains (2) summary
    COG2319
    Location:101515
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:223265
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29921563..29938891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)