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NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]

Gene ID: 7182, updated on 13-Apr-2025

Summary

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Official Symbol
NR2C2provided by HGNC
Official Full Name
nuclear receptor subfamily 2 group C member 2provided by HGNC
Primary source
HGNC:HGNC:7972
See related
Ensembl:ENSG00000177463 MIM:601426; AllianceGenome:HGNC:7972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR4; TAK1
Summary
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 9.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See NR2C2 in Genome Data Viewer
Location:
3p25.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14947583..15049273)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14950033..15051696)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14989090..15090780)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14845672-14846414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14852491-14852991 Neighboring gene long intergenic non-protein coding RNA 2011 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14855464-14855666 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene Sharpr-MPRA regulatory region 8692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14905091-14905672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14920327-14920828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14941355-14942238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14942239-14943121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14955453-14956275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14956276-14957097 Neighboring gene uncharacterized LOC105376963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14962633-14963132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:14963648-14964847 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14965692-14965871 Neighboring gene Sharpr-MPRA regulatory region 15385 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14988241-14988930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14989619-14990306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14990307-14990994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19523 Neighboring gene FGD5 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15066535-15067034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19525 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14100 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15139860-15140724 Neighboring gene rabenosyn, RAB effector Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:15149813-15150312 Neighboring gene ribosomal protein S24 pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Recent advances in the study of testicular nuclear receptor 4. Ding XF, et al. J Zhejiang Univ Sci B, 2013 Mar. PMID 23463759, Free PMC Article
  2. TAK1 mediates the collagen-II-dependent induction of the COX-2 gene and PGE2 release in primary human chondrocytes. Klatt AR, et al. Connect Tissue Res, 2010 Dec. PMID 20604713
  3. The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. Zhou XE, et al. J Biol Chem, 2011 Jan 28. PMID 21068381, Free PMC Article
  4. Mycobacterium tuberculosis keto-mycolic acid and macrophage nuclear receptor TR4 modulate foamy biogenesis in granulomas: a case of a heterologous and noncanonical ligand-receptor pair. Dkhar HK, et al. J Immunol, 2014 Jul 1. PMID 24907344
  5. Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. Shi L, et al. PLoS Genet, 2014 May. PMID 24811540, Free PMC Article

See all (181) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
    Title: Thrombospondin-1 Regulates Trophoblast Necroptosis via NEDD4-Mediated Ubiquitination of TAK1 in Preeclampsia.
  2. TR4 worsen urosepsis by regulating GSDMD.
    Title: TR4 worsen urosepsis by regulating GSDMD.
  3. Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
    Title: Structures of human TR4LBD-JAZF1 and TR4DBD-DNA complexes reveal the molecular basis of transcriptional regulation.
  4. HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
    Title: HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer.
  5. Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
    Title: Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
  6. Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
    Title: Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
  7. The stabilization of yes-associated protein by TGFbeta-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
    Title: The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells.
  8. Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
    Title: Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway.
  9. Use of miR145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
    Title: Use of miR‑145 and testicular nuclear receptor 4 inhibition to reduce chemoresistance to docetaxel in prostate cancer.
  10. LncRNA H19 aggravates TNF-alpha-induced inflammatory injury via TAK1 pathway in MH7A cells.
    Title: LncRNA H19 aggravates TNF-α-induced inflammatory injury via TAK1 pathway in MH7A cells.
Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of embryonic development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 2 group C member 2
Names
Nuclear hormone receptor TR4
orphan nuclear receptor TAK1
orphan nuclear receptor TR4
orphan receptor TR4
testicular nuclear receptor 4

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291694.2 → NP_001278623.1  nuclear receptor subfamily 2 group C member 2 isoform 2

    See identical proteins and their annotated locations for NP_001278623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090937, AC090954, AI986459, AK290590
    Consensus CDS
    CCDS74905.1
    UniProtKB/Swiss-Prot
    A8K3H5, B6ZGT8, P49116, P55092
    UniProtKB/TrEMBL
    Q6PHZ7
    Related
    ENSP00000388387.1, ENST00000425241.6
    Conserved Domains (2) summary
    cd06952
    Location:361 → 582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112 → 198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  2. NM_003298.5 → NP_003289.2  nuclear receptor subfamily 2 group C member 2 isoform 1

    See identical proteins and their annotated locations for NP_003289.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090937, AC090954, AI986459, AK290590, L27586
    Consensus CDS
    CCDS2621.1
    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Related
    ENSP00000320447.6, ENST00000323373.10
    Conserved Domains (2) summary
    cd06952
    Location:380 → 601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131 → 217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    14947583..15049273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448826.1 → XP_047304782.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  2. XM_047448825.1 → XP_047304781.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  3. XM_047448830.1 → XP_047304786.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  4. XM_047448829.1 → XP_047304785.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/TrEMBL
    Q6PHZ7

  5. XM_011534058.4 → XP_011532360.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    See identical proteins and their annotated locations for XP_011532360.1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  6. XM_047448836.1 → XP_047304792.1  nuclear receptor subfamily 2 group C member 2 isoform X7

    UniProtKB/TrEMBL
    Q6PHZ7

  7. XM_011534063.4 → XP_011532365.1  nuclear receptor subfamily 2 group C member 2 isoform X3

    See identical proteins and their annotated locations for XP_011532365.1

    Conserved Domains (2) summary
    cd06952
    Location:394 → 615
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:145 → 231
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  8. XM_011534064.4 → XP_011532366.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    See identical proteins and their annotated locations for XP_011532366.1

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:380 → 601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131 → 217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  9. XM_047448827.1 → XP_047304783.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  10. XM_011534065.4 → XP_011532367.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    See identical proteins and their annotated locations for XP_011532367.1

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:380 → 601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131 → 217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  11. XM_011534061.4 → XP_011532363.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    See identical proteins and their annotated locations for XP_011532363.1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  12. XM_047448837.1 → XP_047304793.1  nuclear receptor subfamily 2 group C member 2 isoform X7

    UniProtKB/TrEMBL
    Q6PHZ7

  13. XM_047448832.1 → XP_047304788.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  14. XM_047448838.1 → XP_047304794.1  nuclear receptor subfamily 2 group C member 2 isoform X8

    UniProtKB/TrEMBL
    Q6PHZ7

  15. XM_047448835.1 → XP_047304791.1  nuclear receptor subfamily 2 group C member 2 isoform X6

    UniProtKB/TrEMBL
    Q6PHZ7

  16. XM_011534059.3 → XP_011532361.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    See identical proteins and their annotated locations for XP_011532361.1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  17. XM_047448831.1 → XP_047304787.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  18. XM_047448828.1 → XP_047304784.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  19. XM_047448824.1 → XP_047304780.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:413 → 634
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:164 → 250
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  20. XM_047448834.1 → XP_047304790.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Related
    ENSP00000483059.1, ENST00000617312.4

  21. XM_011534066.4 → XP_011532368.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    See identical proteins and their annotated locations for XP_011532368.1

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7
    Conserved Domains (2) summary
    cd06952
    Location:380 → 601
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:131 → 217
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

  22. XM_047448833.1 → XP_047304789.1  nuclear receptor subfamily 2 group C member 2 isoform X4

    UniProtKB/TrEMBL
    Q6PHZ7

  23. XM_024453739.2 → XP_024309507.1  nuclear receptor subfamily 2 group C member 2 isoform X9

    Conserved Domains (2) summary
    cd06952
    Location:182 → 403
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cl02596
    Location:1 → 19
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    14950033..15051696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347716.1 → XP_054203691.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  2. XM_054347714.1 → XP_054203689.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  3. XM_054347721.1 → XP_054203696.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  4. XM_054347719.1 → XP_054203694.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/TrEMBL
    Q6PHZ7

  5. XM_054347711.1 → XP_054203686.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  6. XM_054347728.1 → XP_054203703.1  nuclear receptor subfamily 2 group C member 2 isoform X7

    UniProtKB/TrEMBL
    Q6PHZ7

  7. XM_054347720.1 → XP_054203695.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  8. XM_054347724.1 → XP_054203699.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7

  9. XM_054347717.1 → XP_054203692.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  10. XM_054347725.1 → XP_054203700.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7

  11. XM_054347713.1 → XP_054203688.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  12. XM_054347729.1 → XP_054203704.1  nuclear receptor subfamily 2 group C member 2 isoform X7

    UniProtKB/TrEMBL
    Q6PHZ7

  13. XM_054347723.1 → XP_054203698.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  14. XM_054347730.1 → XP_054203705.1  nuclear receptor subfamily 2 group C member 2 isoform X8

    UniProtKB/TrEMBL
    Q6PHZ7

  15. XM_054347727.1 → XP_054203702.1  nuclear receptor subfamily 2 group C member 2 isoform X6

    UniProtKB/TrEMBL
    Q6PHZ7

  16. XM_054347715.1 → XP_054203690.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  17. XM_054347722.1 → XP_054203697.1  nuclear receptor subfamily 2 group C member 2 isoform X3

  18. XM_054347718.1 → XP_054203693.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  19. XM_054347712.1 → XP_054203687.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/TrEMBL
    Q6PHZ7

  20. XM_054347726.1 → XP_054203701.1  nuclear receptor subfamily 2 group C member 2 isoform X5

    UniProtKB/TrEMBL
    A0A024R2N9, F2YGU2, Q6PHZ7

  21. XM_054347731.1 → XP_054203706.1  nuclear receptor subfamily 2 group C member 2 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49116.1 GenPept UniProtKB/Swiss-Prot:P49116

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