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TPP2 tripeptidyl peptidase 2 [ Homo sapiens (human) ]

Gene ID: 7174, updated on 5-Jul-2020

Summary

Official Symbol
TPP2provided by HGNC
Official Full Name
tripeptidyl peptidase 2provided by HGNC
Primary source
HGNC:HGNC:12016
See related
Ensembl:ENSG00000134900 MIM:190470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPP-2; TPPII; TPP-II
Summary
This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See TPP2 in Genome Data Viewer
Location:
13q33.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (102596985..102679958)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (103249286..103331524)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 14 Neighboring gene FGF14 antisense RNA 2 Neighboring gene uncharacterized LOC107984588 Neighboring gene methyltransferase like 21C Neighboring gene uncharacterized LOC105370337 Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40359

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
tripeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein polyubiquitination TAS
Traceable Author Statement
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tripeptidyl-peptidase 2
Names
tripeptidyl aminopeptidase
tripeptidyl-peptidase II
NP_001317517.1
NP_001354876.1
NP_003282.2
XP_005254127.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_063544.1 RefSeqGene

    Range
    5001..87973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1341

mRNA and Protein(s)

  1. NM_001330588.2NP_001317517.1  tripeptidyl-peptidase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is longer than isoform 1.
    Source sequence(s)
    AU132468, BC039905, BF514671, BM684792, BX370108, DB303355, M73047, N27441
    Consensus CDS
    CCDS81777.1
    UniProtKB/Swiss-Prot
    P29144
    UniProtKB/TrEMBL
    Q5VZU9
    Related
    ENSP00000365220.3, ENST00000376052.5
    Conserved Domains (2) summary
    cd04857
    Location:14489
    Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
    pfam12580
    Location:777960
    TPPII; Tripeptidyl peptidase II
  2. NM_001367947.1NP_001354876.1  tripeptidyl-peptidase 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) has the same N- and C-termini, but is longer than isoform 1.
    Source sequence(s)
    AL158063
  3. NM_003291.4NP_003282.2  tripeptidyl-peptidase 2 isoform 1

    See identical proteins and their annotated locations for NP_003282.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest, but most predominant, isoform (1).
    Source sequence(s)
    AU132468, BC039905, BF514671, BM684792, DB303355, M73047, N27441
    Consensus CDS
    CCDS9502.1
    UniProtKB/Swiss-Prot
    P29144
    Related
    ENSP00000365233.4, ENST00000376065.8
    Conserved Domains (2) summary
    cd04857
    Location:14489
    Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
    pfam12580
    Location:777960
    TPPII; Tripeptidyl peptidase II

RNA

  1. NR_160411.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL158063

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    102596985..102679958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254070.2XP_005254127.1  tripeptidyl-peptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_005254127.1

    Conserved Domains (3) summary
    cd04857
    Location:14489
    Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
    pfam00082
    Location:233500
    Peptidase_S8; Subtilase family
    pfam12580
    Location:777960
    TPPII; Tripeptidyl peptidase II

RNA

  1. XR_001749654.2 RNA Sequence

  2. XR_243046.2 RNA Sequence

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