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Mus81 MUS81 structure-specific endonuclease subunit [ Mus musculus (house mouse) ]

Gene ID: 71711, updated on 10-Feb-2024

Summary

Official Symbol
Mus81provided by MGI
Official Full Name
MUS81 structure-specific endonuclease subunitprovided by MGI
Primary source
MGI:MGI:1918961
See related
Ensembl:ENSMUSG00000024906 AllianceGenome:MGI:1918961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200008A18Rik
Summary
Predicted to enable 3'-flap endonuclease activity. Predicted to be involved in DNA recombination; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process, endonucleolytic; DNA repair; and response to intra-S DNA damage checkpoint signaling. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 19.3), cerebellum adult (RPKM 15.2) and 28 other tissues See more
Orthologs
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Genomic context

See Mus81 in Genome Data Viewer
Location:
19 A; 19 4.34 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5532589..5538461, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5482561..5488389, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor (acidic) intracellular binding protein Neighboring gene cathepsin W Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5488369-5488552 Neighboring gene STARR-positive B cell enhancer ABC_E779 Neighboring gene STARR-positive B cell enhancer ABC_E8730 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5491370-5491523 Neighboring gene cofilin 1, non-muscle Neighboring gene sorting nexin 32 Neighboring gene NSE3 homolog, SMC5-SMC6 complex component like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3'-flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to crossover junction DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables crossover junction DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic intra-S DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
 
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of endodeoxyribonuclease complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear replication fork NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in replication fork ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
crossover junction endonuclease MUS81
Names
MUS81 endonuclease homolog
NP_082153.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027877.4NP_082153.3  crossover junction endonuclease MUS81

    See identical proteins and their annotated locations for NP_082153.3

    Status: VALIDATED

    Source sequence(s)
    AA014278, AC126029, AK004647, AK145858, BY208661
    Consensus CDS
    CCDS29467.1
    UniProtKB/Swiss-Prot
    Q8R356, Q91ZJ0
    UniProtKB/TrEMBL
    F8WIN9
    Related
    ENSMUSP00000114895.2, ENSMUST00000124334.8
    Conserved Domains (2) summary
    COG1948
    Location:248515
    MUS81; ERCC4-type nuclease [Replication, recombination and repair]
    pfam02732
    Location:273415
    ERCC4; ERCC4 domain

RNA

  1. NR_153768.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126029, AK145858
    Related
    ENSMUST00000025841.4
  2. NR_153769.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC126029

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5532589..5538461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003952818.2 RNA Sequence

  2. XR_003952819.2 RNA Sequence

  3. XR_003952817.2 RNA Sequence