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Galnt14 polypeptide N-acetylgalactosaminyltransferase 14 [ Mus musculus (house mouse) ]

Gene ID: 71685, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt14provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 14provided by MGI
Primary source
MGI:MGI:1918935
See related
Ensembl:ENSMUSG00000024064 AllianceGenome:MGI:1918935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610033M06Rik
Summary
Predicted to enable carbohydrate binding activity; metal ion binding activity; and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including nervous system and sensory organ. Orthologous to human GALNT14 (polypeptide N-acetylgalactosaminyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 4.0), CNS E18 (RPKM 1.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 44.88 cM; 17 E2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (73800202..74019138, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (73493207..73712138, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E330032C10 gene Neighboring gene STARR-positive B cell enhancer ABC_E10970 Neighboring gene STARR-positive B cell enhancer ABC_E7556 Neighboring gene calpain 13 Neighboring gene STARR-seq mESC enhancer starr_43202 Neighboring gene predicted gene, 46602 Neighboring gene STARR-seq mESC enhancer starr_43203 Neighboring gene predicted gene, 52320 Neighboring gene EH-domain containing 3 Neighboring gene predicted gene, 53977

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
  2. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  3. Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes. Gezelius H, et al. Cereb Cortex, 2017 Nov 1. PMID 27655933, Free PMC Article
  4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
  5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 14
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14
galNAc-T14
polypeptide GalNAc transferase 14
pp-GaNTase 14
protein-UDP acetylgalactosaminyltransferase 14
NP_082140.2
XP_006525003.1
XP_006525004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027864.2 → NP_082140.2  polypeptide N-acetylgalactosaminyltransferase 14

    See identical proteins and their annotated locations for NP_082140.2

    Status: VALIDATED

    Source sequence(s)
    AK078292, BC117800, BY733448
    Consensus CDS
    CCDS28965.1
    UniProtKB/Swiss-Prot
    Q60GT2, Q8BTI6, Q8BVG5, Q9DCJ2
    UniProtKB/TrEMBL
    Q08EC9
    Related
    ENSMUSP00000024858.6, ENSMUST00000024858.12
    Conserved Domains (4) summary
    cd02510
    Location:114 → 408
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:422 → 547
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:422 → 545
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:111 → 337
    Glyco_tranf_2_3; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    73800202..74019138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524941.4 → XP_006525004.1  polypeptide N-acetylgalactosaminyltransferase 14 isoform X2

    Conserved Domains (2) summary
    pfam00652
    Location:153 → 276
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:42 → 139
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_006524940.4 → XP_006525003.1  polypeptide N-acetylgalactosaminyltransferase 14 isoform X1

    Conserved Domains (1) summary
    cl11394
    Location:114 → 310
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_003952183.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVG5.2 GenPept UniProtKB/Swiss-Prot:Q8BVG5

Gene LinkOut

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