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Mier1 MEIR1 treanscription regulator [ Mus musculus (house mouse) ]

Gene ID: 71148, updated on 26-Mar-2023

Summary

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Official Symbol
Mier1provided by MGI
Official Full Name
MEIR1 treanscription regulatorprovided by MGI
Primary source
MGI:MGI:1918398
See related
Ensembl:ENSMUSG00000028522 AllianceGenome:MGI:1918398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
er1; 4933425I22Rik; 5830411K19Rik
Summary
Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to contribute to histone deacetylase activity. Predicted to be involved in histone deacetylation and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Orthologous to human MIER1 (MIER1 transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.8), liver E14 (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mier1 in Genome Data Viewer
Location:
4; 4 C6
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102971521..103022951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103114324..103165754)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene insulin-like 5 Neighboring gene dynein axonemal intermediate chain 4 Neighboring gene solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 Neighboring gene RIKEN cDNA 4921539E11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein expression of the transcriptional regulator MI-ER1 alpha in adult mouse tissues. Thorne LB, et al. J Mol Histol, 2008 Feb. PMID 17622490
  2. Cloning and characterization of the mouse ortholog of mi-er1. Thorne LB, et al. DNA Seq, 2005 Jun. PMID 16147882
  3. Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism. Lakisic G, et al. PLoS Genet, 2016 Mar. PMID 26938916, Free PMC Article
  4. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Fisher CL, et al. Nucleic Acids Res, 2017 Dec 1. PMID 28981838, Free PMC Article
  5. Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Hammock EA, et al. Neural Dev, 2010 Dec 1. PMID 21122108, Free PMC Article

See all (27) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biochemical analysis of the BAHD1-associated multiprotein complex identifies MIER proteins as novel partners of BAHD1 and suggests that BAHD1-MIER interaction forms a hub for histone deacetylases and methyltransferases
    Title: Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.
  2. This study represents the first immunohistochemical analysis of MI-ER1alpha expression in mammals.
    Title: Protein expression of the transcriptional regulator MI-ER1 alpha in adult mouse tissues.
  3. characterization of the mouse ortholog of mi-er1
    Title: Cloning and characterization of the mouse ortholog of mi-er1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1610, MGC107532

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mesoderm induction early response protein 1
Names
early response 1
mesoderm induction early response 1 homolog (Xenopus laevis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039081.3 → NP_001034170.1  mesoderm induction early response protein 1 isoform b

    See identical proteins and their annotated locations for NP_001034170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at an alternate start codon, compared to variant 4. It encodes isoform b, which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AL844176
    Consensus CDS
    CCDS38825.1
    UniProtKB/Swiss-Prot
    Q5UAK0, Q9D402
    UniProtKB/TrEMBL
    A0A8C6GTT0, Q32P49, Q8C929
    Related
    ENSMUSP00000102470.2, ENSMUST00000106857.8
    Conserved Domains (3) summary
    smart00717
    Location:287 → 332
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:287 → 331
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:181 → 230
    ELM2; ELM2 domain

  2. NM_001286221.1 → NP_001273150.1  mesoderm induction early response protein 1 isoform c precursor

    See identical proteins and their annotated locations for NP_001273150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AK136467, AL844176, AV322829, BC108273, CN538186
    Consensus CDS
    CCDS71432.1
    UniProtKB/Swiss-Prot
    Q5UAK0
    UniProtKB/TrEMBL
    Q32P49, Q8C929
    Related
    ENSMUSP00000095558.4, ENSMUST00000097945.10
    Conserved Domains (3) summary
    smart00717
    Location:332 → 377
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:332 → 376
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:226 → 275
    ELM2; ELM2 domain

  3. NM_001286222.2 → NP_001273151.1  mesoderm induction early response protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001273151.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 4. Variants 1 and 3 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AL844176
    Consensus CDS
    CCDS18408.1
    UniProtKB/Swiss-Prot
    Q5UAK0
    UniProtKB/TrEMBL
    A0A8C6GT51, Q32P49, Q8C929
    Related
    ENSMUSP00000102471.2, ENSMUST00000106858.8
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

  4. NM_001286223.1 → NP_001273152.1  mesoderm induction early response protein 1 isoform d

    See identical proteins and their annotated locations for NP_001273152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 4. It encodes isoform d, which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AK136467, AK168693, AV322829, BQ562973, CJ099524, CN701986
    UniProtKB/Swiss-Prot
    Q5UAK0
    UniProtKB/TrEMBL
    Q8C929
    Conserved Domains (3) summary
    smart00717
    Location:286 → 331
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:286 → 330
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:180 → 229
    ELM2; ELM2 domain

  5. NM_001404080.1 → NP_001391009.1  mesoderm induction early response protein 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL844176
    UniProtKB/TrEMBL
    A0A8C6GT51

  6. NM_001404081.1 → NP_001391010.1  mesoderm induction early response protein 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL844176
    UniProtKB/TrEMBL
    A0A8C6GT51

  7. NM_001404082.1 → NP_001391011.1  mesoderm induction early response protein 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL844176
    UniProtKB/TrEMBL
    A0A8C6GT51

  8. NM_001404084.1 → NP_001391013.1  mesoderm induction early response protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL844176

  9. NM_001404085.1 → NP_001391014.1  mesoderm induction early response protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL844176

  10. NM_027696.4 → NP_081972.2  mesoderm induction early response protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_081972.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an alternate exon in the 5' coding region, compared to variant 4. Variants 1 and 3 encode the same isoform (a), which is shorter and has a distinct N-terminus, compared to isoform c.
    Source sequence(s)
    AL844176
    Consensus CDS
    CCDS18408.1
    UniProtKB/Swiss-Prot
    Q5UAK0
    UniProtKB/TrEMBL
    A0A8C6GT51, Q32P49, Q8C929
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    102971521..103022951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503399.3 → XP_006503462.1  mesoderm induction early response protein 1 isoform X2

    Conserved Domains (2) summary
    cd11661
    Location:338 → 382
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:232 → 282
    ELM2; ELM2 domain

  2. XM_030253777.1 → XP_030109637.1  mesoderm induction early response protein 1 isoform X4

    Conserved Domains (2) summary
    cd11661
    Location:260 → 304
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:154 → 204
    ELM2; ELM2 domain

  3. XM_006503398.4 → XP_006503461.1  mesoderm induction early response protein 1 isoform X1

    Conserved Domains (2) summary
    cd11661
    Location:353 → 397
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:247 → 297
    ELM2; ELM2 domain

  4. XM_030253779.1 → XP_030109639.1  mesoderm induction early response protein 1 isoform X5

    Conserved Domains (2) summary
    cd11661
    Location:402 → 446
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:296 → 346
    ELM2; ELM2 domain

  5. XM_030253776.1 → XP_030109636.1  mesoderm induction early response protein 1 isoform X3

    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

  6. XM_006503402.2 → XP_006503465.1  mesoderm induction early response protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5UAK0
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

  7. XM_030253778.2 → XP_030109638.1  mesoderm induction early response protein 1 isoform X4

    Conserved Domains (2) summary
    cd11661
    Location:260 → 304
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:154 → 204
    ELM2; ELM2 domain

  8. XM_006503401.5 → XP_006503464.1  mesoderm induction early response protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006503464.1

    UniProtKB/Swiss-Prot
    Q5UAK0
    UniProtKB/TrEMBL
    A0A8C6GT51
    Related
    ENSMUSP00000030247.5, ENSMUST00000030247.11
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

  9. XM_036164424.1 → XP_036020317.1  mesoderm induction early response protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C6GT51
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

  10. XM_036164426.1 → XP_036020319.1  mesoderm induction early response protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C6GT51
    Conserved Domains (2) summary
    cd11661
    Location:304 → 348
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    pfam01448
    Location:198 → 247
    ELM2; ELM2 domain

RNA

  1. XR_004941961.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5UAK0.2 GenPept UniProtKB/Swiss-Prot:Q5UAK0

Gene LinkOut

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