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Atoh8 atonal bHLH transcription factor 8 [ Mus musculus (house mouse) ]

Gene ID: 71093, updated on 12-May-2024

Summary

Official Symbol
Atoh8provided by MGI
Official Full Name
atonal bHLH transcription factor 8provided by MGI
Primary source
MGI:MGI:1918343
See related
Ensembl:ENSMUSG00000037621 AllianceGenome:MGI:1918343
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hath6; Math6; okadin; bHLHa21; 4933425C05Rik
Summary
Enables DNA-binding transcription factor activity and DNA-binding transcription factor binding activity. Involved in formation of primary germ layer; myoblast proliferation; and negative regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including aorta; central nervous system; genitourinary system; heart; and lung. Orthologous to human ATOH8 (atonal bHLH transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 68.7), lung adult (RPKM 9.9) and 9 other tissues See more
Orthologs
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Genomic context

See Atoh8 in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72183158..72212765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72206174..72235780, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene spermine synthase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9667 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 5 Neighboring gene RIKEN cDNA 4933431G14 gene Neighboring gene STARR-seq mESC enhancer starr_16279 Neighboring gene STARR-seq mESC enhancer starr_16280 Neighboring gene VISTA enhancer mm123 Neighboring gene predicted gene, 52906 Neighboring gene predicted gene, 30782 Neighboring gene surfactant associated protein B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in formation of primary germ layer IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor Atoh8
Names
atonal homolog 8
basic helix-loop-helix transcription factor 6
helix-loop-helix protein mATH-6
protein atonal homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153778.3NP_722473.1  transcription factor Atoh8

    See identical proteins and their annotated locations for NP_722473.1

    Status: PROVISIONAL

    Source sequence(s)
    AC122864
    Consensus CDS
    CCDS39511.1
    UniProtKB/Swiss-Prot
    Q8C1I7, Q99NA2
    Related
    ENSMUSP00000036981.8, ENSMUST00000042646.8
    Conserved Domains (1) summary
    pfam00010
    Location:232283
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72183158..72212765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_377494.5 RNA Sequence