U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stox2 storkhead box 2 [ Mus musculus (house mouse) ]

Gene ID: 71069, updated on 5-Mar-2024

Summary

Official Symbol
Stox2provided by MGI
Official Full Name
storkhead box 2provided by MGI
Primary source
MGI:MGI:1918319
See related
Ensembl:ENSMUSG00000038143 AllianceGenome:MGI:1918319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1392; 4933409N07Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within response to bacterium. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human STOX2 (storkhead box 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 6.7), CNS E14 (RPKM 6.3) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Stox2 in Genome Data Viewer
Location:
8 B1.1; 8 26.61 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47633083..47866943, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47180048..47413847, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 6 Neighboring gene predicted gene, 31231 Neighboring gene STARR-seq mESC enhancer starr_21399 Neighboring gene predicted gene, 51569 Neighboring gene STARR-seq mESC enhancer starr_21401 Neighboring gene predicted gene, 51570 Neighboring gene STARR-seq mESC enhancer starr_21406 Neighboring gene STARR-seq mESC enhancer starr_21407 Neighboring gene predicted gene, 39171 Neighboring gene STARR-seq mESC enhancer starr_21409 Neighboring gene predicted gene, 22857 Neighboring gene trafficking protein particle complex 11 Neighboring gene STARR-positive B cell enhancer ABC_E1754

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107432

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114311.1NP_001107783.1  storkhead-box protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001107783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC105173, AC134442
    Consensus CDS
    CCDS52548.1
    UniProtKB/Swiss-Prot
    B2RR59, Q3TRF0, Q497F9, Q499E5, Q6ZPS3, Q8CDI1
    Related
    ENSMUSP00000078190.6, ENSMUST00000079195.6
    Conserved Domains (1) summary
    pfam10264
    Location:64140
    Stork_head; Winged helix Storkhead-box1 domain
  2. NM_001286376.1NP_001273305.1  storkhead-box protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, lacks a portion of the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC105173, AC134442, AK129346
    Consensus CDS
    CCDS85535.1
    UniProtKB/Swiss-Prot
    Q499E5
    Related
    ENSMUSP00000147477.2, ENSMUST00000211737.2
    Conserved Domains (1) summary
    pfam10264
    Location:64140
    Stork_head; Winged helix Storkhead-box1 domain
  3. NM_001363119.1NP_001350048.1  storkhead-box protein 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC105173, AC134442
  4. NM_175162.4NP_780371.3  storkhead-box protein 2 isoform 2

    See identical proteins and their annotated locations for NP_780371.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' and 3' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC102862, AC134442
    Consensus CDS
    CCDS40336.1
    UniProtKB/Swiss-Prot
    Q499E5
    Related
    ENSMUSP00000105996.3, ENSMUST00000110367.10
    Conserved Domains (1) summary
    pfam10264
    Location:179
    Stork_head; Winged helix Storkhead-box1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    47633083..47866943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243766.2XP_030099626.1  storkhead-box protein 2 isoform X1

    Conserved Domains (1) summary
    pfam10264
    Location:128204
    Stork_head; Winged helix Storkhead-box1 domain
  2. XM_036154293.1XP_036010186.1  storkhead-box protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RMH0
    Related
    ENSMUSP00000148776.2, ENSMUST00000211882.2
    Conserved Domains (1) summary
    pfam10264
    Location:127205
    Stork_head; Winged helix Storkhead-box1 domain
  3. XM_036154295.1XP_036010188.1  storkhead-box protein 2 isoform X6

  4. XM_036154296.1XP_036010189.1  storkhead-box protein 2 isoform X6

  5. XM_006509495.5XP_006509558.1  storkhead-box protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006509558.1

    Conserved Domains (1) summary
    pfam10264
    Location:278
    Stork_head; Winged helix Storkhead-box1 domain
  6. XM_006509492.5XP_006509555.1  storkhead-box protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006509555.1

    Conserved Domains (1) summary
    pfam10264
    Location:278
    Stork_head; Winged helix Storkhead-box1 domain
  7. XM_030243768.2XP_030099628.1  storkhead-box protein 2 isoform X7

  8. XM_036154294.1XP_036010187.1  storkhead-box protein 2 isoform X5

    Conserved Domains (1) summary
    pfam10264
    Location:179
    Stork_head; Winged helix Storkhead-box1 domain
  9. XM_030243767.2XP_030099627.1  storkhead-box protein 2 isoform X6

  10. XM_017312966.3XP_017168455.1  storkhead-box protein 2 isoform X4

    Conserved Domains (1) summary
    pfam10264
    Location:278
    Stork_head; Winged helix Storkhead-box1 domain
  11. XM_006509491.5XP_006509554.1  storkhead-box protein 2 isoform X3

    Conserved Domains (1) summary
    pfam10264
    Location:31107
    Stork_head; Winged helix Storkhead-box1 domain
  12. XM_011242237.3XP_011240539.1  storkhead-box protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011240539.1

    UniProtKB/Swiss-Prot
    Q499E5
    Related
    ENSMUSP00000147281.2, ENSMUST00000210030.2
    Conserved Domains (1) summary
    pfam10264
    Location:179
    Stork_head; Winged helix Storkhead-box1 domain
  13. XM_006509494.4XP_006509557.1  storkhead-box protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006509557.1

    Conserved Domains (1) summary
    pfam10264
    Location:278
    Stork_head; Winged helix Storkhead-box1 domain