U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hexim2 hexamethylene bis-acetamide inducible 2 [ Mus musculus (house mouse) ]

Gene ID: 71059, updated on 25-Jun-2024

Summary

Go to the top of the page Help
Official Symbol
Hexim2provided by MGI
Official Full Name
hexamethylene bis-acetamide inducible 2provided by MGI
Primary source
MGI:MGI:1918309
See related
Ensembl:ENSMUSG00000043372 AllianceGenome:MGI:1918309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933402L21Rik
Summary
Predicted to enable 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Predicted to be involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in heart. Orthologous to human HEXIM2 (HEXIM P-TEFb complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 10.3), CNS E18 (RPKM 3.7) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hexim2 in Genome Data Viewer
Location:
11 E1; 11 66.71 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103014086..103030734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103123260..103139908)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4004 Neighboring gene STARR-positive B cell enhancer ABC_E738 Neighboring gene hexamethylene bis-acetamide inducible 1 Neighboring gene STARR-positive B cell enhancer ABC_E379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103003747-103004003 Neighboring gene STARR-positive B cell enhancer ABC_E10717 Neighboring gene predicted gene, 51919 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103036322-103036635 Neighboring gene formin-like 1 Neighboring gene uncharacterized LOC118567870

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Montano MM, et al. Circ Res, 2008 Feb 29. PMID 18079413, Free PMC Article
  2. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Okamura D, et al. Genes Dev, 2012 Nov 15. PMID 23154982, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 7SK snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7SK snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein HEXIM2
Names
hexamthylene bis-acetamide inducible 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130515.1 → NP_001123987.1  protein HEXIM2

    See identical proteins and their annotated locations for NP_001123987.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK160110, BC026458, BI076707
    Consensus CDS
    CCDS25514.1
    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Related
    ENSMUSP00000102652.2, ENSMUST00000107037.8
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

  2. NM_001130516.1 → NP_001123988.1  protein HEXIM2

    See identical proteins and their annotated locations for NP_001123988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK160110, BC026458, BI076707
    Consensus CDS
    CCDS25514.1
    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

  3. NM_027658.2 → NP_081934.1  protein HEXIM2

    See identical proteins and their annotated locations for NP_081934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    BC026458, BI076707, BY295186
    Consensus CDS
    CCDS25514.1
    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Related
    ENSMUSP00000053678.5, ENSMUST00000062530.5
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103014086..103030734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534231.4 → XP_006534294.1  protein HEXIM2 isoform X1

    See identical proteins and their annotated locations for XP_006534294.1

    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

  2. XM_006534230.4 → XP_006534293.1  protein HEXIM2 isoform X1

    See identical proteins and their annotated locations for XP_006534293.1

    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

  3. XM_006534229.3 → XP_006534292.1  protein HEXIM2 isoform X1

    See identical proteins and their annotated locations for XP_006534292.1

    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

  4. XM_030246320.1 → XP_030102180.1  protein HEXIM2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein

  5. XM_006534228.3 → XP_006534291.1  protein HEXIM2 isoform X1

    See identical proteins and their annotated locations for XP_006534291.1

    UniProtKB/Swiss-Prot
    Q3TVI4, Q9D4C7
    Conserved Domains (1) summary
    pfam15313
    Location:101 → 226
    HEXIM; Hexamethylene bis-acetamide-inducible protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TVI4.1 GenPept UniProtKB/Swiss-Prot:Q3TVI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools