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Pcgf6 polycomb group ring finger 6 [ Mus musculus (house mouse) ]

Gene ID: 71041, updated on 12-May-2024

Summary

Official Symbol
Pcgf6provided by MGI
Official Full Name
polycomb group ring finger 6provided by MGI
Primary source
MGI:MGI:1918291
See related
Ensembl:ENSMUSG00000025050 AllianceGenome:MGI:1918291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBLR; Rnf134; 4933407A11Rik
Summary
Predicted to enable protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Is expressed in eye; limb; trunk somite; and urinary system. Orthologous to human PCGF6 (polycomb group ring finger 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 18.0), whole brain E14.5 (RPKM 15.5) and 27 other tissues See more
Orthologs
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Genomic context

See Pcgf6 in Genome Data Viewer
Location:
19 C3; 19 39.11 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47022056..47039379, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47033617..47050939, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene lysophosphatidic acid receptor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46336 Neighboring gene internexin neuronal intermediate filament protein, alpha Neighboring gene STARR-positive B cell enhancer ABC_E11037 Neighboring gene STARR-seq mESC enhancer starr_46338 Neighboring gene STARR-positive B cell enhancer ABC_E1979 Neighboring gene predicted gene, 23140 Neighboring gene TATA-box binding protein associated factor 5 Neighboring gene ATP synthase membrane subunit k

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC106622

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polycomb group RING finger protein 6
Names
Mel18- and Bmi1-like RING finger protein
ring finger protein 134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360632.1NP_001347561.1  polycomb group RING finger protein 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108814, BC089460
    Conserved Domains (2) summary
    pfam16207
    Location:284331
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    cd16738
    Location:133177
    RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
  2. NM_027654.3NP_081930.1  polycomb group RING finger protein 6 isoform 1

    See identical proteins and their annotated locations for NP_081930.1

    Status: VALIDATED

    Source sequence(s)
    AC108814, BC089460
    Consensus CDS
    CCDS29885.1
    UniProtKB/Swiss-Prot
    Q99NA9
    Related
    ENSMUSP00000026032.6, ENSMUST00000026032.7
    Conserved Domains (2) summary
    pfam00097
    Location:137175
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:266322
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

RNA

  1. NR_133574.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108814, BC089460
    Related
    ENSMUST00000235633.2
  2. NR_153762.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108814, BC089460

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47022056..47039379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527338.5XP_006527401.1  polycomb group RING finger protein 6 isoform X1

    UniProtKB/TrEMBL
    Q3V1H7
    Conserved Domains (2) summary
    cd16738
    Location:133177
    RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
    cl28922
    Location:255313
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. XM_030251075.1XP_030106935.1  polycomb group RING finger protein 6 isoform X2

    UniProtKB/TrEMBL
    Q3V1H7
    Conserved Domains (2) summary
    cd16738
    Location:133177
    RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
    cd17085
    Location:255307
    RAWUL_PCGF6; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 6 (PCGF6) and similar proteins
  3. XM_036161687.1XP_036017580.1  polycomb group RING finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A494B9Z3
    Conserved Domains (1) summary
    cd16738
    Location:133177
    RING-HC_PCGF6; RING finger found in polycomb group RING finger protein 6 (PCGF6) and similar proteins

RNA

  1. XR_001782614.3 RNA Sequence

  2. XR_386508.5 RNA Sequence

  3. XR_003952816.1 RNA Sequence

  4. XR_003952814.1 RNA Sequence

  5. XR_004940173.1 RNA Sequence