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TM4SF4 transmembrane 4 L six family member 4 [ Homo sapiens (human) ]

Gene ID: 7104, updated on 5-Jul-2020

Summary

Official Symbol
TM4SF4provided by HGNC
Official Full Name
transmembrane 4 L six family member 4provided by HGNC
Primary source
HGNC:HGNC:11856
See related
Ensembl:ENSG00000169903 MIM:606567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILTMP; il-TMP
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
Expression
Biased expression in gall bladder (RPKM 554.1), duodenum (RPKM 308.9) and 2 other tissues See more
Orthologs

Genomic context

See TM4SF4 in Genome Data Viewer
Location:
3q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (149474697..149503394)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149192368..149221181)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 8 Neighboring gene FKBP prolyl isomerase 1A pseudogene 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene RNA, U6 small nuclear 1098, pseudogene Neighboring gene WW domain containing transcription regulator 1 Neighboring gene WWTR1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31015

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transmembrane 4 L6 family member 4
Names
intestinal and liver (il) tetraspan membrane protein
intestine and liver tetraspan membrane protein
transmembrane 4 superfamily member 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004617.4NP_004608.1  transmembrane 4 L6 family member 4

    See identical proteins and their annotated locations for NP_004608.1

    Status: REVIEWED

    Source sequence(s)
    BG656032, BP294159, U31449
    Consensus CDS
    CCDS46932.1
    UniProtKB/Swiss-Prot
    P48230
    Related
    ENSP00000305852.4, ENST00000305354.5
    Conserved Domains (1) summary
    pfam05805
    Location:1186
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    149474697..149503394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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