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Abraxas1 BRCA1 A complex subunit [ Mus musculus (house mouse) ]

Gene ID: 70681, updated on 8-Feb-2024

Summary

Official Symbol
Abraxas1provided by MGI
Official Full Name
BRCA1 A complex subunitprovided by MGI
Primary source
MGI:MGI:1917931
See related
Ensembl:ENSMUSG00000035234 AllianceGenome:MGI:1917931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc98; Fam175a; 3830405G04Rik; 5630400M01Rik
Summary
Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; mitotic spindle assembly; and protein K63-linked deubiquitination. Predicted to act upstream of or within DNA repair and chromatin organization. Predicted to be located in nuclear body. Predicted to be part of BRCA1-A complex. Predicted to be active in nucleus. Orthologous to human ABRAXAS1 (abraxas 1, BRCA1 A complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 4.3), placenta adult (RPKM 4.0) and 28 other tissues See more
Orthologs
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Genomic context

See Abraxas1 in Genome Data Viewer
Location:
5 E4; 5 48.52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100952668..100968816, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100804802..100845864, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene helicase, POLQ-like Neighboring gene STARR-positive B cell enhancer ABC_E6351 Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene STARR-seq mESC enhancer starr_13731 Neighboring gene predicted gene, 26286 Neighboring gene RIKEN cDNA 4930458D05 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
BRCA1-A complex subunit Abraxas 1
Names
coiled-coil domain containing 98
coiled-coil domain-containing protein 98
family with sequence similarity 175, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172405.4NP_765993.1  BRCA1-A complex subunit Abraxas 1

    See identical proteins and their annotated locations for NP_765993.1

    Status: VALIDATED

    Source sequence(s)
    AC161510
    Consensus CDS
    CCDS19469.1
    UniProtKB/Swiss-Prot
    Q3TJ88, Q8BFV6, Q8BPZ8, Q8BT69, Q8K2T7
    Related
    ENSMUSP00000055895.7, ENSMUST00000055245.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100952668..100968816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535218.3XP_006535281.1  BRCA1-A complex subunit Abraxas 1 isoform X3

    See identical proteins and their annotated locations for XP_006535281.1