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Fra10ac1 FRA10A associated CGG repeat 1 [ Mus musculus (house mouse) ]

Gene ID: 70567, updated on 2-Nov-2024

Summary

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Official Symbol
Fra10ac1provided by MGI
Official Full Name
FRA10A associated CGG repeat 1provided by MGI
Primary source
MGI:MGI:1917817
See related
Ensembl:ENSMUSG00000054237 AllianceGenome:MGI:1917817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730455O13Rik
Summary
Predicted to enable phosphatase activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Orthologous to human FRA10AC1 (FRA10A associated CGG repeat 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.1), CNS E14 (RPKM 7.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Fra10ac1 in Genome Data Viewer
Location:
19 C2; 19 32.82 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38176925..38213078, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38188477..38224630, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32440 Neighboring gene phosphodiesterase 6C, cGMP specific, cone, alpha prime Neighboring gene predicted gene, 52398 Neighboring gene STARR-seq mESC enhancer starr_46076 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:38298641-38298824 Neighboring gene STARR-seq mESC enhancer starr_46077 Neighboring gene STARR-seq mESC enhancer starr_46079 Neighboring gene predicted gene, 32574 Neighboring gene predicted gene, 32491 Neighboring gene predicted gene, 32771 Neighboring gene leucine-rich repeat LGI family, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein. Sarafidou T, et al. Genomics, 2004 Jul. PMID 15203205
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein FRA10AC1 homolog
Names
FRA10AC1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081075.2 → NP_001074544.1  protein FRA10AC1 homolog isoform 1

    See identical proteins and their annotated locations for NP_001074544.1

    Status: VALIDATED

    Source sequence(s)
    AC112153
    Consensus CDS
    CCDS37972.1
    UniProtKB/Swiss-Prot
    F8VPM5, Q1LZ54, Q3T9W6, Q8BP78
    Related
    ENSMUSP00000070534.6, ENSMUST00000067167.6
    Conserved Domains (1) summary
    pfam09725
    Location:104 → 216
    Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

  2. NM_027466.1 → NP_081742.1  protein FRA10AC1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112153, AK017666, BB669528
    Related
    ENSMUST00000238007.2
    Conserved Domains (1) summary
    pfam09725
    Location:104 → 208
    Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38176925..38213078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527335.4 → XP_006527398.1  protein FRA10AC1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006527398.1

    UniProtKB/Swiss-Prot
    F8VPM5, Q1LZ54, Q3T9W6, Q8BP78
    Conserved Domains (1) summary
    pfam09725
    Location:104 → 216
    Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

  2. XM_006527334.3 → XP_006527397.1  protein FRA10AC1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006527397.1

    UniProtKB/Swiss-Prot
    F8VPM5, Q1LZ54, Q3T9W6, Q8BP78
    Conserved Domains (1) summary
    pfam09725
    Location:104 → 216
    Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1

  3. XM_017318291.2 → XP_017173780.1  protein FRA10AC1 homolog isoform X1

    Conserved Domains (1) summary
    pfam09725
    Location:193 → 305
    Fra10Ac1; Folate-sensitive fragile site protein Fra10Ac1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP78.3 GenPept UniProtKB/Swiss-Prot:Q8BP78

Gene LinkOut

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