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Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 70560, updated on 9-Sep-2018

Summary

Official Symbol
Wars2provided by MGI
Official Full Name
tryptophanyl tRNA synthetase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:1917810
See related
Ensembl:ENSMUSG00000004233 Vega:OTTMUSG00000006862
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TrpRS; AI413375; 5730427B17Rik; 9430020O07Rik
Expression
Ubiquitous expression in limb E14.5 (RPKM 1.9), CNS E11.5 (RPKM 1.5) and 28 other tissues See more
Orthologs

Genomic context

See Wars2 in Genome Data Viewer
Location:
3; 3 F2.2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (99140618..99221230)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (98945013..99024126)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene catechol O-methyltransferase domain-containing protein 1 pseudogene Neighboring gene predicted gene, 40105 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene microRNA 6481 Neighboring gene predicted gene, 38468 Neighboring gene predicted gene, 46817 Neighboring gene T-box 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Chemically induced (ENU) (1)  1 citation

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasculogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tryptophan--tRNA ligase, mitochondrial
Names
(Mt)TrpRS
tryptophanyl-tRNA synthetase, mitochondrial
NP_081738.2
XP_006502115.1
XP_006502116.1
XP_011238525.1
XP_017175206.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027462.4NP_081738.2  tryptophan--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_081738.2

    Status: PROVISIONAL

    Source sequence(s)
    AC080018
    Consensus CDS
    CCDS17672.1
    UniProtKB/Swiss-Prot
    Q9CYK1
    Related
    ENSMUSP00000004343.2, OTTMUSP00000007286, ENSMUST00000004343.6, OTTMUST00000015865
    Conserved Domains (2) summary
    cd00806
    Location:36312
    TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
    PRK00927
    Location:35360
    PRK00927; tryptophanyl-tRNA synthetase; Reviewed

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    99140618..99221230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502052.3XP_006502115.1  tryptophan--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00015
    Location:53249
    nt_trans; nucleotidyl transferase superfamily
  2. XM_006502053.3XP_006502116.1  tryptophan--tRNA ligase, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00015
    Location:59195
    nt_trans; nucleotidyl transferase superfamily
  3. XM_017319717.1XP_017175206.1  tryptophan--tRNA ligase, mitochondrial isoform X1

  4. XM_011240223.2XP_011238525.1  tryptophan--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00015
    Location:1183
    nt_trans; nucleotidyl transferase superfamily

RNA

  1. XR_001783742.1 RNA Sequence

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