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Rufy2 RUN and FYVE domain-containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70432, updated on 2-Nov-2024

Summary

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Official Symbol
Rufy2provided by MGI
Official Full Name
RUN and FYVE domain-containing 2provided by MGI
Primary source
MGI:MGI:1917682
See related
Ensembl:ENSMUSG00000020070 AllianceGenome:MGI:1917682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Denn; LZ-FYVE; ZFYVE13; 2610111M19Rik
Summary
Predicted to enable SH3 domain binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; respiratory system; sensory organ; skeleton; and skin. Orthologous to human RUFY2 (RUN and FYVE domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 11.0), CNS E14 (RPKM 10.6) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Rufy2 in Genome Data Viewer
Location:
10 B4; 10 32.51 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62815947..62852988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62980174..63017209)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62409633-62409742 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger protein. Dunkelberg JC, et al. DNA Cell Biol, 2001 Jul. PMID 11506704
  2. Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. Yang J, et al. J Biol Chem, 2002 Aug 16. PMID 11877430
  3. Rufy3, a protein specifically expressed in neurons, interacts with actin-bundling protein Fascin to control the growth of axons. Wei Z, et al. J Neurochem, 2014 Sep. PMID 24720729
  4. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722, Free PMC Article
  5. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RUN and FYVE domain-containing protein 2
Names
leucine zipper FYVE-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027425.4 → NP_081701.2  RUN and FYVE domain-containing protein 2

    See identical proteins and their annotated locations for NP_081701.2

    Status: VALIDATED

    Source sequence(s)
    AC113107
    Consensus CDS
    CCDS48582.1
    UniProtKB/Swiss-Prot
    Q69ZH1, Q8R4C2
    UniProtKB/TrEMBL
    B2RQ36
    Related
    ENSMUSP00000113429.2, ENSMUST00000119567.8
    Conserved Domains (6) summary
    cd15759
    Location:534 → 604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 168
    RUN; RUN domain
    pfam06156
    Location:223 → 295
    DUF972; Protein of unknown function (DUF972)
    pfam09728
    Location:209 → 535
    Taxilin; Myosin-like coiled-coil protein
    cd16269
    Location:497 → 507
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:326 → 510
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62815947..62852988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514087.3 → XP_006514150.1  RUN and FYVE domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:210 → 535
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15759
    Location:533 → 603
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45 → 166
    RUN; RUN domain

  2. XM_036156001.1 → XP_036011894.1  RUN and FYVE domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:13 → 266
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28890
    Location:268 → 338
    FYVE_like_SF; FYVE domain like superfamily

  3. XM_011243562.4 → XP_011241864.1  RUN and FYVE domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:165 → 520
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15759
    Location:518 → 588
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:29 → 150
    RUN; RUN domain

RNA

  1. XR_004936273.1 RNA Sequence

  2. XR_003948801.2 RNA Sequence

  3. XR_004936275.1 RNA Sequence

  4. XR_004936272.1 RNA Sequence

  5. XR_003948799.2 RNA Sequence

  6. XR_003948800.2 RNA Sequence

  7. XR_003948802.2 RNA Sequence

  8. XR_004936274.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4C2.2 GenPept UniProtKB/Swiss-Prot:Q8R4C2

Gene LinkOut

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