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Rufy2 RUN and FYVE domain-containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70432, updated on 21-Apr-2024

Summary

Official Symbol
Rufy2provided by MGI
Official Full Name
RUN and FYVE domain-containing 2provided by MGI
Primary source
MGI:MGI:1917682
See related
Ensembl:ENSMUSG00000020070 AllianceGenome:MGI:1917682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Denn; LZ-FYVE; ZFYVE13; 2610111M19Rik
Summary
Predicted to enable SH3 domain binding activity. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; respiratory system; sensory organ; skeleton; and skin. Orthologous to human RUFY2 (RUN and FYVE domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.0), CNS E14 (RPKM 10.6) and 22 other tissues See more
Orthologs
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Genomic context

Location:
10 B4; 10 32.51 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62815947..62852988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62980174..63017209)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62409633-62409742 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RUN and FYVE domain-containing protein 2
Names
leucine zipper FYVE-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027425.4NP_081701.2  RUN and FYVE domain-containing protein 2

    See identical proteins and their annotated locations for NP_081701.2

    Status: VALIDATED

    Source sequence(s)
    AC113107
    Consensus CDS
    CCDS48582.1
    UniProtKB/Swiss-Prot
    Q69ZH1, Q8R4C2
    UniProtKB/TrEMBL
    B2RQ36
    Related
    ENSMUSP00000113429.2, ENSMUST00000119567.8
    Conserved Domains (6) summary
    cd15759
    Location:534604
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45168
    RUN; RUN domain
    pfam06156
    Location:223295
    DUF972; Protein of unknown function (DUF972)
    pfam09728
    Location:209535
    Taxilin; Myosin-like coiled-coil protein
    cd16269
    Location:497507
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:326510
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62815947..62852988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514087.3XP_006514150.1  RUN and FYVE domain-containing protein 2 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:210535
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15759
    Location:533603
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:45166
    RUN; RUN domain
  2. XM_036156001.1XP_036011894.1  RUN and FYVE domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    COG1196
    Location:13266
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl28890
    Location:268338
    FYVE_like_SF; FYVE domain like superfamily
  3. XM_011243562.4XP_011241864.1  RUN and FYVE domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    COG1196
    Location:165520
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd15759
    Location:518588
    FYVE_RUFY2; FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins
    pfam02759
    Location:29150
    RUN; RUN domain

RNA

  1. XR_004936273.1 RNA Sequence

  2. XR_003948801.2 RNA Sequence

  3. XR_004936275.1 RNA Sequence

  4. XR_004936272.1 RNA Sequence

  5. XR_003948799.2 RNA Sequence

  6. XR_003948800.2 RNA Sequence

  7. XR_003948802.2 RNA Sequence

  8. XR_004936274.1 RNA Sequence