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Gtpbp3 GTP binding protein 3 [ Mus musculus (house mouse) ]

Gene ID: 70359, updated on 6-Jun-2024

Summary

Official Symbol
Gtpbp3provided by MGI
Official Full Name
GTP binding protein 3provided by MGI
Primary source
MGI:MGI:1917609
See related
Ensembl:ENSMUSG00000007610 AllianceGenome:MGI:1917609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410009F13Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in tRNA methylation and tRNA wobble uridine modification. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 23. Orthologous to human GTPBP3 (GTP binding protein 3, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 16.6), adrenal adult (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Gtpbp3 in Genome Data Viewer
Location:
8 B3.3; 8 34.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71938788..71952268)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71486144..71499624)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene plasmalemma vesicle associated protein Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like Neighboring gene STARR-seq mESC enhancer starr_21821 Neighboring gene STARR-positive B cell enhancer ABC_E1759 Neighboring gene bone marrow stromal cell antigen 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102372

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tRNA modification GTPase GTPBP3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032544.4NP_115933.2  tRNA modification GTPase GTPBP3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_115933.2

    Status: VALIDATED

    Source sequence(s)
    AC127416
    Consensus CDS
    CCDS40384.1
    UniProtKB/Swiss-Prot
    Q58E73, Q923K4, Q99M99
    UniProtKB/TrEMBL
    B2RRS4
    Related
    ENSMUSP00000007754.7, ENSMUST00000007754.13
    Conserved Domains (3) summary
    cd04164
    Location:248416
    trmE; trmE is a tRNA modification GTPase
    PRK05291
    Location:35492
    trmE; tRNA modification GTPase TrmE; Reviewed
    pfam10396
    Location:35152
    TrmE_N; GTP-binding protein TrmE N-terminus

RNA

  1. NR_157144.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127416
  2. NR_157145.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127416
    Related
    ENSMUST00000095259.10
  3. NR_157146.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK046330, BY287260, BY588239
  4. NR_157147.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC055716, BY287260
    Related
    ENSMUST00000127741.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71938788..71952268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509737.4XP_006509800.1  tRNA modification GTPase GTPBP3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509800.1

    Conserved Domains (1) summary
    PRK05291
    Location:35323
    trmE; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE

RNA

  1. XR_379045.4 RNA Sequence