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Ube3d ubiquitin protein ligase E3D [ Mus musculus (house mouse) ]

Gene ID: 70348, updated on 6-Jun-2024

Summary

Official Symbol
Ube3dprovided by MGI
Official Full Name
ubiquitin protein ligase E3Dprovided by MGI
Primary source
MGI:MGI:1917598
See related
Ensembl:ENSMUSG00000032415 AllianceGenome:MGI:1917598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ube2cbp; 2610018I03Rik
Summary
Predicted to enable cyclin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human UBE3D (ubiquitin protein ligase E3D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.4), CNS E14 (RPKM 1.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ube3d in Genome Data Viewer
Location:
9 E3.1; 9 46.58 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86189364..86347003, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86307234..86464976, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330154J02 gene Neighboring gene STARR-seq mESC enhancer starr_24825 Neighboring gene trophoblast glycoprotein Neighboring gene STARR-seq mESC enhancer starr_24827 Neighboring gene STARR-seq mESC enhancer starr_24828 Neighboring gene STARR-seq mESC enhancer starr_24829 Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene DOP1 leucine zipper like protein A Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene RWD domain containing 2A Neighboring gene phosphoglucomutase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC144619

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase E3D
Names
HECT-type E3 ubiquitin transferase E3D
UbcH10 binding protein with a hect-like domain
ubcH10-binding protein with a HECT-like domain
ubiquitin-conjugating enzyme E2C binding protein
NP_001405800.1
NP_001405801.1
NP_001405802.1
NP_081670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418871.1NP_001405800.1  E3 ubiquitin-protein ligase E3D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998
    UniProtKB/TrEMBL
    Q9D0H0
  2. NM_001418872.1NP_001405801.1  E3 ubiquitin-protein ligase E3D isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998
  3. NM_001418873.1NP_001405802.1  E3 ubiquitin-protein ligase E3D isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998
  4. NM_027394.3NP_081670.1  E3 ubiquitin-protein ligase E3D isoform 1

    See identical proteins and their annotated locations for NP_081670.1

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998
    Consensus CDS
    CCDS40713.1
    UniProtKB/Swiss-Prot
    Q8BX13
    UniProtKB/TrEMBL
    Q9D0H0
    Related
    ENSMUSP00000034986.8, ENSMUST00000034986.14
    Conserved Domains (1) summary
    pfam09814
    Location:13358
    HECT_2; HECT-like Ubiquitin-conjugating enzyme (E2)-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86189364..86347003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)