Ube2cbp ubiquitin-conjugating enzyme E2C binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2cbpprovided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2C binding proteinprovided by MGI
Primary source: MGI:MGI:1917598
See related: Ensembl:ENSMUSG00000032415 AllianceGenome:MGI:1917598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ube3d; 2610018I03Rik
Summary: Predicted to enable cyclin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human UBE3D (ubiquitin protein ligase E3D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 1.4), CNS E14 (RPKM 1.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9; 9 E3.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (86189287..86347027, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (86307234..86464976, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
Title: UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
Title: UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
Ablation of the UBE3D protein lead to an abnormal amount of pigment granules deposited in retinal pigment epithelium microvilli area and an abnormal response on electroretinography (ERG) in UBE3D(+/-) heterozygous mice.
Title: Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

RH101866 (e-PCR)
- UniSTS:116773

NoName (e-PCR)
- UniSTS:488813

NoName (e-PCR)
- UniSTS:236211

Homology

Homologs of the Ube2cbp gene: The Ube2cbp gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 497 organisms have orthologs with human gene Ube2cbp
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein conjugating enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase E3D

Names: HECT-type E3 ubiquitin transferase E3D; UbcH10 binding protein with a hect-like domain; ubcH10-binding protein with a HECT-like domain

NP_081670.1

EC 2.3.2.26

XP_006511495.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027394.2 → NP_081670.1 E3 ubiquitin-protein ligase E3D

See identical proteins and their annotated locations for NP_081670.1

Status: PROVISIONAL

Source sequence(s)

AK049229

Consensus CDS

CCDS40713.1

UniProtKB/Swiss-Prot

Q8BX13

Related

ENSMUSP00000034986.8, ENSMUST00000034986.14

Conserved Domains (1) summary

pfam09814
Location:13 → 358

HECT_2; HECT-like Ubiquitin-conjugating enzyme (E2)-binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

86189287..86347027 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511432.5 → XP_006511495.1 E3 ubiquitin-protein ligase E3D isoform X1

Conserved Domains (1) summary

pfam09814
Location:26 → 260

HECT_2; HECT-like Ubiquitin-conjugating enzyme (E2)-binding