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Ube3d ubiquitin protein ligase E3D [ Mus musculus (house mouse) ]

Gene ID: 70348, updated on 7-Apr-2025

Summary

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Official Symbol
Ube3dprovided by MGI
Official Full Name
ubiquitin protein ligase E3Dprovided by MGI
Primary source
MGI:MGI:1917598
See related
Ensembl:ENSMUSG00000032415 AllianceGenome:MGI:1917598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ube2cbp; 2610018I03Rik
Summary
Predicted to enable cyclin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human UBE3D (ubiquitin protein ligase E3D). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.4), CNS E14 (RPKM 1.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube3d in Genome Data Viewer
Location:
9 E3.1; 9 46.58 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86189364..86347003, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86307234..86464976, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330154J02 gene Neighboring gene STARR-seq mESC enhancer starr_24825 Neighboring gene trophoblast glycoprotein Neighboring gene STARR-seq mESC enhancer starr_24827 Neighboring gene STARR-seq mESC enhancer starr_24828 Neighboring gene STARR-seq mESC enhancer starr_24829 Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene DOP1 leucine zipper like protein A Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene RWD domain containing 2A Neighboring gene phosphoglucomutase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice. Tao T, et al. J Pathol, 2023 Dec. PMID 37772657
  2. UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells. Heller-Trulli D, et al. Mol Cell Biol, 2022 Dec 15. PMID 36519931, Free PMC Article
  3. Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations. Huang LZ, et al. Nat Commun, 2015 Apr 15. PMID 25872646
  4. UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair. Xu N, et al. Invest Ophthalmol Vis Sci, 2022 Sep 1. PMID 36094642, Free PMC Article
  5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice.
    Title: Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice.
  2. UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
    Title: UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
  3. UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
    Title: UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
  4. Ablation of the UBE3D protein lead to an abnormal amount of pigment granules deposited in retinal pigment epithelium microvilli area and an abnormal response on electroretinography (ERG) in UBE3D(+/-) heterozygous mice.
    Title: Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC144619

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase E3D
Names
HECT-type E3 ubiquitin transferase E3D
UbcH10 binding protein with a hect-like domain
ubcH10-binding protein with a HECT-like domain
ubiquitin-conjugating enzyme E2C binding protein
NP_001405800.1
NP_001405801.1
NP_001405802.1
NP_081670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418871.1 → NP_001405800.1  E3 ubiquitin-protein ligase E3D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998
    UniProtKB/TrEMBL
    Q9D0H0

  2. NM_001418872.1 → NP_001405801.1  E3 ubiquitin-protein ligase E3D isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998

  3. NM_001418873.1 → NP_001405802.1  E3 ubiquitin-protein ligase E3D isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998

  4. NM_001433775.1 → NP_001420704.1  E3 ubiquitin-protein ligase E3D isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998

  5. NM_027394.3 → NP_081670.1  E3 ubiquitin-protein ligase E3D isoform 1

    See identical proteins and their annotated locations for NP_081670.1

    Status: VALIDATED

    Source sequence(s)
    AC137556, AC157998
    Consensus CDS
    CCDS40713.1
    UniProtKB/Swiss-Prot
    Q8BX13
    UniProtKB/TrEMBL
    Q9D0H0
    Related
    ENSMUSP00000034986.8, ENSMUST00000034986.14
    Conserved Domains (1) summary
    pfam09814
    Location:13 → 358
    HECT_2; HECT-like Ubiquitin-conjugating enzyme (E2)-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86189364..86347003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX13.1 GenPept UniProtKB/Swiss-Prot:Q8BX13

Gene LinkOut

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