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Reep6 receptor accessory protein 6 [ Mus musculus (house mouse) ]

Gene ID: 70335, updated on 8-Feb-2024

Summary

Official Symbol
Reep6provided by MGI
Official Full Name
receptor accessory protein 6provided by MGI
Primary source
MGI:MGI:1917585
See related
Ensembl:ENSMUSG00000035504 AllianceGenome:MGI:1917585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dp1l1; 0610011M24Rik
Summary
Involved in regulation of intracellular transport. Located in apical part of cell; endoplasmic reticulum membrane; and rod spherule. Is expressed in several structures, including extraembryonic component; gut; lung; retina; and urinary system. Used to study retinitis pigmentosa 77. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Orthologous to human REEP6 (receptor accessory protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 263.9), liver adult (RPKM 179.2) and 6 other tissues See more
Orthologs
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Genomic context

See Reep6 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80165831..80172275)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80329997..80336441)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene RIKEN cDNA 2310011J03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5155 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene STARR-positive B cell enhancer ABC_E366 Neighboring gene predicted gene, 51809 Neighboring gene ADAMTS-like 5 Neighboring gene polo like kinase 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
NOT located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in rod spherule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor expression-enhancing protein 6
Names
TB2 protein-like 1
deleted in polyposis 1-like 1
polyposis locus protein 1-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204931.1NP_001191860.1  receptor expression-enhancing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001191860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC152062
    Consensus CDS
    CCDS56735.1
    UniProtKB/Swiss-Prot
    Q9JM62
    Related
    ENSMUSP00000100992.2, ENSMUST00000105355.8
    Conserved Domains (1) summary
    pfam03134
    Location:54142
    TB2_DP1_HVA22; TB2/DP1, HVA22 family
  2. NM_139292.2NP_647453.1  receptor expression-enhancing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_647453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB039933, AK002562
    Consensus CDS
    CCDS35979.1
    UniProtKB/Swiss-Prot
    Q8K0X2, Q9JM62
    Related
    ENSMUSP00000140840.2, ENSMUST00000186864.7
    Conserved Domains (1) summary
    pfam03134
    Location:54142
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80165831..80172275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514077.2XP_006514140.1  receptor expression-enhancing protein 6 isoform X1

    Related
    ENSMUSP00000100995.2, ENSMUST00000105358.8
    Conserved Domains (1) summary
    pfam03134
    Location:66143
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RNA

  1. XR_004936271.1 RNA Sequence