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Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 [ Mus musculus (house mouse) ]

Gene ID: 70316, updated on 8-Feb-2024

Summary

Official Symbol
Ndufab1provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase subunit AB1provided by MGI
Primary source
MGI:MGI:1917566
See related
Ensembl:ENSMUSG00000030869 AllianceGenome:MGI:1917566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACP; 8kDa; SDAP; CI-SDAP; 2210401F17Rik; 2310039H15Rik; 2610003B19Rik; 9130423F15Rik
Summary
Predicted to enable acyl binding activity and acyl carrier activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 768.6), duodenum adult (RPKM 586.0) and 16 other tissues See more
Orthologs
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Genomic context

See Ndufab1 in Genome Data Viewer
Location:
7 F2; 7 65.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121686038..121701071, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (122086815..122101848, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E10471 Neighboring gene glutamyl-tRNA synthetase 2, mitochondrial Neighboring gene ubiquitin family domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3748 Neighboring gene partner and localizer of BRCA2 Neighboring gene 60S ribosomal protein L27-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:129276354-129276600 Neighboring gene dynactin 5 Neighboring gene predicted gene 15489

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyl binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acyl carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mitochondrial large ribosomal subunit binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of iron-sulfur cluster assembly complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl carrier protein, mitochondrial
Names
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1
NADH-ubiquinone oxidoreductase 9.6 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360743.1NP_001347672.1  acyl carrier protein, mitochondrial precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC124379, BF019966
    Consensus CDS
    CCDS21809.1
    UniProtKB/Swiss-Prot
    Q9CR21, Q9D726, Q9D7V5
    UniProtKB/TrEMBL
    Q3TJG2, Q569N0
    Related
    ENSMUSP00000102079.3, ENSMUST00000106471.9
    Conserved Domains (1) summary
    cl09936
    Location:66152
    PP-binding; Phosphopantetheine attachment site
  2. NM_001360744.1NP_001347673.1  acyl carrier protein, mitochondrial precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC124379, AK010307
    Consensus CDS
    CCDS21809.1
    UniProtKB/Swiss-Prot
    Q9CR21, Q9D726, Q9D7V5
    UniProtKB/TrEMBL
    Q3TJG2, Q569N0
    Related
    ENSMUSP00000116177.2, ENSMUST00000123296.8
    Conserved Domains (1) summary
    cl09936
    Location:66152
    PP-binding; Phosphopantetheine attachment site
  3. NM_028177.4NP_082453.2  acyl carrier protein, mitochondrial precursor

    See identical proteins and their annotated locations for NP_082453.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AC124379, AK011302
    Consensus CDS
    CCDS21809.1
    UniProtKB/Swiss-Prot
    Q9CR21, Q9D726, Q9D7V5
    UniProtKB/TrEMBL
    Q3TJG2, Q569N0
    Related
    ENSMUSP00000033157.4, ENSMUST00000033157.10
    Conserved Domains (1) summary
    cl09936
    Location:66152
    PP-binding; Phosphopantetheine attachment site

RNA

  1. NR_153798.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124379

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    121686038..121701071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)