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Fuz fuzzy planar cell polarity protein [ Mus musculus (house mouse) ]

Gene ID: 70300, updated on 8-Dec-2022

Summary

Official Symbol
Fuzprovided by MGI
Official Full Name
fuzzy planar cell polarity proteinprovided by MGI
Primary source
MGI:MGI:1917550
See related
Ensembl:ENSMUSG00000011658 AllianceGenome:MGI:1917550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b1273Clo; 2600013E07Rik
Summary
Involved in several processes, including embryonic morphogenesis; non-motile cilium assembly; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and positive regulation of protein processing. Predicted to be located in cell projection; cytoplasm; and cytoskeleton. Is expressed in several structures, including central nervous system; neural ectoderm; and notochord. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human FUZ (fuzzy planar cell polarity protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 71.2), ovary adult (RPKM 43.6) and 27 other tissues See more
Orthologs
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Genomic context

See Fuz in Genome Data Viewer
Location:
7 B3; 7 28.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44544902..44550048)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44894305..44900624)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic neurocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic neurocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of planar polarity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within larynx morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within larynx morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neural crest formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium assembly NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tongue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein fuzzy homolog
Names
fuzzy homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403450.1NP_001390379.1  protein fuzzy homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158231
  2. NM_001403451.1NP_001390380.1  protein fuzzy homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158231
  3. NM_001403452.1NP_001390381.1  protein fuzzy homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158231
  4. NM_001403453.1NP_001390382.1  protein fuzzy homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    A0A140LI55
  5. NM_001403454.1NP_001390383.1  protein fuzzy homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC158231
  6. NM_001403455.1NP_001390384.1  protein fuzzy homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC158231
  7. NM_001403456.1NP_001390385.1  protein fuzzy homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC158231
  8. NM_001403457.1NP_001390386.1  protein fuzzy homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC158231
  9. NM_027376.4NP_081652.2  protein fuzzy homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Consensus CDS
    CCDS52237.1
    UniProtKB/Swiss-Prot
    Q3UYI6
    UniProtKB/TrEMBL
    E9QL29
    Related
    ENSMUSP00000071194.8, ENSMUST00000071207.14

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44544902..44550048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541192.5XP_006541255.1  protein fuzzy homolog isoform X1

  2. XM_006541193.5XP_006541256.1  protein fuzzy homolog isoform X2

  3. XM_006541194.5XP_006541257.1  protein fuzzy homolog isoform X3

    UniProtKB/TrEMBL
    A0A140LI55
    Related
    ENSMUSP00000146681.2, ENSMUST00000209039.2