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Kif18b kinesin family member 18B [ Mus musculus (house mouse) ]

Gene ID: 70218, updated on 11-Apr-2024

Summary

Official Symbol
Kif18bprovided by MGI
Official Full Name
kinesin family member 18Bprovided by MGI
Primary source
MGI:MGI:2446979
See related
Ensembl:ENSMUSG00000051378 AllianceGenome:MGI:2446979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3000004C01Rik
Summary
Predicted to enable ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in several processes, including microtubule depolymerization; mitotic sister chromatid segregation; and regulation of cell division. Predicted to act upstream of or within cell division. Predicted to be located in cytosol; microtubule; and nuclear body. Predicted to be part of kinesin complex. Predicted to be active in mitotic spindle astral microtubule; mitotic spindle midzone; and nucleus. Orthologous to human KIF18B (kinesin family member 18B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 15.9), liver E14.5 (RPKM 14.4) and 17 other tissues See more
Orthologs
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Genomic context

Location:
11 E1; 11 66.48 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102796344..102815960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102905518..102925134, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187, member A Neighboring gene glial fibrillary acidic protein Neighboring gene predicted gene, 34560 Neighboring gene STARR-seq mESC enhancer starr_30821 Neighboring gene complement component 1, q subcomponent-like 1 Neighboring gene RIKEN cDNA 2410004I01 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytoskeletal motor activity ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in astral microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule end ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
kinesin-like protein KIF18B
Names
N-8 kinesin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197959.2NP_932063.2  kinesin-like protein KIF18B

    See identical proteins and their annotated locations for NP_932063.2

    Status: VALIDATED

    Source sequence(s)
    BC057614, BQ571943, BQ833635, BY312717
    Consensus CDS
    CCDS25508.1
    UniProtKB/Swiss-Prot
    Q3U0T0, Q6PFD6, Q80V20
    Related
    ENSMUSP00000021311.10, ENSMUST00000021311.10
    Conserved Domains (1) summary
    cd01370
    Location:18353
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102796344..102815960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249243.1XP_011247545.1  kinesin-like protein KIF18B isoform X1

    See identical proteins and their annotated locations for XP_011247545.1

    UniProtKB/Swiss-Prot
    Q3U0T0, Q6PFD6, Q80V20
    Conserved Domains (1) summary
    cd01370
    Location:18353
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup