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Med23 mediator complex subunit 23 [ Mus musculus (house mouse) ]

Gene ID: 70208, updated on 5-Apr-2024

Summary

Official Symbol
Med23provided by MGI
Official Full Name
mediator complex subunit 23provided by MGI
Primary source
MGI:MGI:1917458
See related
Ensembl:ENSMUSG00000019984 AllianceGenome:MGI:1917458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sno; Sur2; Crsp3; ESTM7; 130kDa; snouty; mKIAA1216; 3000002A17Rik
Summary
Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of T cell extravasation and positive regulation of gene expression. Part of mediator complex. Is expressed in several structures, including genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MED23 (mediator complex subunit 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs
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Genomic context

See Med23 in Genome Data Viewer
Location:
10 A4; 10
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24745889..24789358)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24869986..24913529)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 1 Neighboring gene STARR-seq mESC enhancer starr_26082 Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 3 Neighboring gene STARR-seq mESC enhancer starr_26086 Neighboring gene STARR-seq mESC enhancer starr_26088 Neighboring gene STARR-seq mESC enhancer starr_26089 Neighboring gene STARR-seq mESC enhancer starr_26090 Neighboring gene STARR-positive B cell enhancer ABC_E6826 Neighboring gene predicted gene, 23410 Neighboring gene microRNA 6905 Neighboring gene predicted gene, 40616 Neighboring gene arginase, liver Neighboring gene predicted gene, 36228

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 23
Names
CRSP complex subunit 3
cofactor required for Sp1 transcriptional activation subunit 3
cofactor required for Sp1 transcriptional activation, subunit 3 (130kD)
mSur-2
protein sur-2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166416.2NP_001159888.2  mediator of RNA polymerase II transcription subunit 23 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159502
    Consensus CDS
    CCDS48522.1
    Related
    ENSMUSP00000090316.8, ENSMUST00000092646.13
  2. NM_027347.4NP_081623.4  mediator of RNA polymerase II transcription subunit 23 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC159502
    Consensus CDS
    CCDS35871.2
    UniProtKB/Swiss-Prot
    Q6ZPV7, Q80YQ2, Q8CEC3, Q8K587, Q9CXY8
    Related
    ENSMUSP00000020159.10, ENSMUST00000020159.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    24745889..24789358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155991.1XP_036011884.1  mediator of RNA polymerase II transcription subunit 23 isoform X1

    UniProtKB/TrEMBL
    F8WJB0
    Conserved Domains (1) summary
    pfam11573
    Location:41278
    Med23; Mediator complex subunit 23