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TESK1 testis associated actin remodelling kinase 1 [ Homo sapiens (human) ]

Gene ID: 7016, updated on 9-Sep-2018

Summary

Official Symbol
TESK1provided by HGNC
Official Full Name
testis associated actin remodelling kinase 1provided by HGNC
Primary source
HGNC:HGNC:11731
See related
Ensembl:ENSG00000107140 MIM:601782; Vega:OTTHUMG00000019863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in fat (RPKM 24.9), testis (RPKM 24.6) and 25 other tissues See more
Orthologs

Genomic context

See TESK1 in Genome Data Viewer
Location:
9p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (35605284..35610041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35605281..35610038)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene family with sequence similarity 166 member B Neighboring gene ribosomal protein S29 pseudogene 17 Neighboring gene microRNA 4667 Neighboring gene CD72 molecule Neighboring gene uncharacterized LOC101926948 Neighboring gene signaling threshold regulating transmembrane adaptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of stress fiber assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity testis-specific protein kinase 1
Names
testicular protein kinase 1
testis-specific kinase 1
NP_001305159.1
NP_006276.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318230.1NP_001305159.1  dual specificity testis-specific protein kinase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL357874, BC011799, BC067130
    UniProtKB/Swiss-Prot
    Q15569
    Conserved Domains (1) summary
    cl21453
    Location:46158
    PKc_like; Protein Kinases, catalytic domain
  2. NM_006285.2NP_006276.2  dual specificity testis-specific protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_006276.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF507907, BC011799, BC067130
    Consensus CDS
    CCDS6580.1
    UniProtKB/Swiss-Prot
    Q15569
    UniProtKB/TrEMBL
    Q8NFJ4
    Related
    ENSP00000338127.5, OTTHUMP00000021332, ENST00000336395.5, OTTHUMT00000052314
    Conserved Domains (2) summary
    smart00219
    Location:61311
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:63318
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    35605284..35610041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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