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DYNLT3 dynein light chain Tctex-type 3 [ Homo sapiens (human) ]

Gene ID: 6990, updated on 2-Nov-2024

Summary

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Official Symbol
DYNLT3provided by HGNC
Official Full Name
dynein light chain Tctex-type 3provided by HGNC
Primary source
HGNC:HGNC:11694
See related
Ensembl:ENSG00000165169 MIM:300302; AllianceGenome:HGNC:11694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP3; TCTE1L; TCTEX1L
Summary
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in adrenal (RPKM 36.5), esophagus (RPKM 35.0) and 24 other tissues See more
Orthologs
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Genomic context

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See DYNLT3 in Genome Data Viewer
Location:
Xp11.4
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37838836..37847571, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (37242419..37251154, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37698089..37706824, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H2A.L variant histone 1M, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29518 Neighboring gene X-linked Kx blood group antigen, Kell and VPS13A binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29520 Neighboring gene cytochrome b-245 beta chain Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20733 Neighboring gene RNA, U6 small nuclear 49, pseudogene Neighboring gene synaptotagmin like 5 Neighboring gene sterol-C4-methyl oxidase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition. Wang H, et al. Cancer Med, 2023 Jul. PMID 37260179, Free PMC Article
  2. Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains. Wilson MJ, et al. Cell Motil Cytoskeleton, 2001 Aug. PMID 11746667
  3. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. Roux AF, et al. Hum Mol Genet, 1994 Feb. PMID 8004092
  4. Cytoplasmic dynein contains a family of differentially expressed light chains. King SM, et al. Biochemistry, 1998 Oct 27. PMID 9790665
  5. Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. Yeh TY, et al. J Cell Sci, 2005 Aug 1. PMID 16079286

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition.
    Title: The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition.
  2. Age-associated genes in human mammary gland drive human breast cancer progression.
    Title: Age-associated genes in human mammary gland drive human breast cancer progression.
  3. These data show that both DYNLT1 and DYNLT3 interact with L2 of human papillomavirus 16 during virus infection.
    Title: Identification of the dynein light chains required for human papillomavirus infection.
  4. The N-terminal half of pUL35, in particular residues 30-43, was identified as a common region for the binding of DYNLT1 and DYNLT3.
    Title: Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26).
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle astral microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein light chain Tctex-type 3
Names
protein 91/23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016797.1 RefSeqGene

    Range
    5066..13801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006520.3 → NP_006511.1  dynein light chain Tctex-type 3

    See identical proteins and their annotated locations for NP_006511.1

    Status: REVIEWED

    Source sequence(s)
    BC000968, DA342302
    Consensus CDS
    CCDS14243.1
    UniProtKB/Swiss-Prot
    P51808, Q6ICS3
    UniProtKB/TrEMBL
    F2Z328
    Related
    ENSP00000367841.4, ENST00000378578.9
    Conserved Domains (1) summary
    cd21463
    Location:16 → 112
    DLC-like_DYNLT3; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    37838836..37847571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    37242419..37251154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51808.1 GenPept UniProtKB/Swiss-Prot:P51808

Gene LinkOut

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