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DYNLT3 dynein light chain Tctex-type 3 [ Homo sapiens (human) ]

Gene ID: 6990, updated on 8-Jul-2018
Official Symbol
DYNLT3provided by HGNC
Official Full Name
dynein light chain Tctex-type 3provided by HGNC
Primary source
HGNC:HGNC:11694
See related
Ensembl:ENSG00000165169 MIM:300302; Vega:OTTHUMG00000033172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP3; TCTE1L; TCTEX1L
Summary
This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in adrenal (RPKM 36.5), esophagus (RPKM 35.0) and 24 other tissues See more
Orthologs
See DYNLT3 in Genome Data Viewer
Location:
Xp11.4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (37838836..37847636, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37698089..37706889, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene X-linked Kx blood group Neighboring gene cytochrome b-245 beta chain Neighboring gene RNA, U6 small nuclear 49, pseudogene Neighboring gene synaptotagmin like 5 Neighboring gene sterol-C4-methyl oxidase pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle astral microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dynein light chain Tctex-type 3
Names
protein 91/23

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016797.1 RefSeqGene

    Range
    5001..13801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006520.2NP_006511.1  dynein light chain Tctex-type 3

    See identical proteins and their annotated locations for NP_006511.1

    Status: REVIEWED

    Source sequence(s)
    BC000968, DA342302, DB492712
    Consensus CDS
    CCDS14243.1
    UniProtKB/Swiss-Prot
    P51808
    Related
    ENSP00000367841.4, OTTHUMP00000031912, ENST00000378578.8, OTTHUMT00000080876
    Conserved Domains (1) summary
    pfam03645
    Location:18113
    Tctex-1; Tctex-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    37838836..37847636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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