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Mterf4 mitochondrial transcription termination factor 4 [ Mus musculus (house mouse) ]

Gene ID: 69821, updated on 2-Nov-2024

Summary

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Official Symbol
Mterf4provided by MGI
Official Full Name
mitochondrial transcription termination factor 4provided by MGI
Primary source
MGI:MGI:1918355
See related
Ensembl:ENSMUSG00000026273 AllianceGenome:MGI:1918355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mterfd2; 1810059A23Rik; 4933412H03Rik
Summary
Predicted to enable rRNA binding activity. Acts upstream of or within several processes, including mitochondrial transcription; protein targeting to mitochondrion; and ribosome assembly. Located in mitochondrion. Is expressed in several structures, including embryo ectoderm; limb bud; nervous system; sensory organ; and tongue. Orthologous to human MTERF4 (mitochondrial transcription termination factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.6), CNS E14 (RPKM 6.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mterf4 in Genome Data Viewer
Location:
1 D; 1 47.24 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93228927..93233601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93301205..93305879, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ciliary rootlet coiled-coil, rootletin family member 2 Neighboring gene STARR-seq mESC enhancer starr_01724 Neighboring gene STARR-seq mESC enhancer starr_01726 Neighboring gene sushi, nidogen and EGF-like domains 1 Neighboring gene microRNA 6901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95202393-95202604 Neighboring gene predicted gene 28535 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E3291 Neighboring gene STARR-positive B cell enhancer ABC_E7733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis. Castillo A, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Jun 1. PMID 30690068
  2. Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family. Xu Q, et al. Genes Genet Syst, 2011. PMID 22214595
  3. Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals. Kühl I, et al. Elife, 2017 Nov 14. PMID 29132502, Free PMC Article
  4. Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10. Wang XL, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27894840
  5. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cámara Y, et al. Cell Metab, 2011 May 4. PMID 21531335

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results demonstrate that MTERF4 regulates mitochondrial protein translation and is essential for proper brown adipose tissue thermogenic activity.
    Title: Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis.
  2. The levels of MTERF4 protein were significantly increased in the hippocampus of APP/PS1 mice, an animal model of Alzheimer's disease.
    Title: Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.
  3. Mterfd2 might have multiple roles in organogenesis.
    Title: Expression profile of mouse Mterfd2, a novel component of the mitochondrial transcription termination factor (MTERF) family.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription termination factor 4, mitochondrial
Names
MTERF domain containing 2
mTERF domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310756.1 → NP_001297685.1  transcription termination factor 4, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK033043, AK079098, DV058715
    Consensus CDS
    CCDS78655.1
    UniProtKB/TrEMBL
    D3Z3A2
    Related
    ENSMUSP00000108566.2, ENSMUST00000112944.8
    Conserved Domains (1) summary
    cl19765
    Location:128 → 223
    mTERF; mTERF

  2. NM_178051.4 → NP_835152.1  transcription termination factor 4, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_835152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033043, AK077142, DV058715
    Consensus CDS
    CCDS35671.1
    UniProtKB/Swiss-Prot
    Q8BVN4, Q99LQ0
    Related
    ENSMUSP00000027492.8, ENSMUST00000027492.14
    Conserved Domains (1) summary
    cl19765
    Location:128 → 302
    mTERF; mTERF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93228927..93233601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024463.1: Suppressed sequence

    Description
    NM_024463.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVN4.1 GenPept UniProtKB/Swiss-Prot:Q8BVN4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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