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Mterf4 mitochondrial transcription termination factor 4 [ Mus musculus (house mouse) ]

Gene ID: 69821, updated on 11-Apr-2024

Summary

Official Symbol
Mterf4provided by MGI
Official Full Name
mitochondrial transcription termination factor 4provided by MGI
Primary source
MGI:MGI:1918355
See related
Ensembl:ENSMUSG00000026273 AllianceGenome:MGI:1918355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mterfd2; 1810059A23Rik; 4933412H03Rik
Summary
Predicted to enable rRNA binding activity. Acts upstream of or within several processes, including mitochondrial transcription; protein targeting to mitochondrion; and ribosome assembly. Located in mitochondrion. Orthologous to human MTERF4 (mitochondrial transcription termination factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.6), CNS E14 (RPKM 6.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mterf4 in Genome Data Viewer
Location:
1 D; 1 47.24 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93228927..93233601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93301205..93305879, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ciliary rootlet coiled-coil, rootletin family member 2 Neighboring gene STARR-seq mESC enhancer starr_01724 Neighboring gene STARR-seq mESC enhancer starr_01726 Neighboring gene sushi, nidogen and EGF-like domains 1 Neighboring gene microRNA 6901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95202393-95202604 Neighboring gene predicted gene 28535 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E3291 Neighboring gene STARR-positive B cell enhancer ABC_E7733

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription termination factor 4, mitochondrial
Names
MTERF domain containing 2
mTERF domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310756.1NP_001297685.1  transcription termination factor 4, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK033043, AK079098, DV058715
    Consensus CDS
    CCDS78655.1
    UniProtKB/TrEMBL
    D3Z3A2
    Related
    ENSMUSP00000108566.2, ENSMUST00000112944.8
    Conserved Domains (1) summary
    cl19765
    Location:128223
    mTERF; mTERF
  2. NM_178051.4NP_835152.1  transcription termination factor 4, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_835152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033043, AK077142, DV058715
    Consensus CDS
    CCDS35671.1
    UniProtKB/Swiss-Prot
    Q8BVN4, Q99LQ0
    Related
    ENSMUSP00000027492.8, ENSMUST00000027492.14
    Conserved Domains (1) summary
    cl19765
    Location:128302
    mTERF; mTERF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93228927..93233601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024463.1: Suppressed sequence

    Description
    NM_024463.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.