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Casz1 castor zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 69743, updated on 12-May-2024

Summary

Official Symbol
Casz1provided by MGI
Official Full Name
castor zinc finger 1provided by MGI
Primary source
MGI:MGI:1196251
See related
Ensembl:ENSMUSG00000028977 AllianceGenome:MGI:1196251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cst; D4Ertd432e; 2410019P08Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and retina morphogenesis in camera-type eye. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Used to study chromosome 1p36 deletion syndrome. Orthologous to human CASZ1 (castor zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 25.0), duodenum adult (RPKM 22.7) and 16 other tissues See more
Orthologs
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Genomic context

See Casz1 in Genome Data Viewer
Location:
4 E2; 4 78.87 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148888823..149039350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148804366..148954893)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32897 Neighboring gene predicted gene, 42350 Neighboring gene STARR-seq mESC enhancer starr_12090 Neighboring gene STARR-seq mESC enhancer starr_12091 Neighboring gene VISTA enhancer mm1532 Neighboring gene predicted gene, 42352 Neighboring gene STARR-seq mESC enhancer starr_12094 Neighboring gene STARR-seq mESC enhancer starr_12095 Neighboring gene predicted gene 15969 Neighboring gene predicted gene 13205 Neighboring gene predicted gene 17029 Neighboring gene VISTA enhancer mm1566 Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene predicted gene, 42351

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC31683

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of retinal cone cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within retinal bipolar neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinal rod cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinal rod cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger protein castor homolog 1
Names
castor homolog 1, zinc finger
castor-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159344.1NP_001152816.1  zinc finger protein castor homolog 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL607145, AL611967
    Consensus CDS
    CCDS51379.1
    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    UniProtKB/TrEMBL
    B1AS46
    Related
    ENSMUSP00000112978.2, ENSMUST00000122222.8
    Conserved Domains (1) summary
    PHA03247
    Location:7991158
    PHA03247; large tegument protein UL36; Provisional
  2. NM_027195.2NP_081471.2  zinc finger protein castor homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC075673, BI738136
    Consensus CDS
    CCDS38973.1
    UniProtKB/Swiss-Prot
    Q9CWL2
    Related
    ENSMUSP00000092035.4, ENSMUST00000094464.10
    Conserved Domains (1) summary
    PHA03247
    Location:7991158
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_161310.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607145, BC040081

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    148888823..149039350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539158.2XP_006539221.1  zinc finger protein castor homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006539221.1

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:7991158
    PHA03247; large tegument protein UL36; Provisional
  2. XM_006539159.5XP_006539222.1  zinc finger protein castor homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006539222.1

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:7991158
    PHA03247; large tegument protein UL36; Provisional
  3. XM_006539157.5XP_006539220.1  zinc finger protein castor homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:8231182
    PHA03247; large tegument protein UL36; Provisional
  4. XM_006539160.5XP_006539223.1  zinc finger protein castor homolog 1 isoform X3

    UniProtKB/Swiss-Prot
    A2A8A1, Q69Z25, Q9CWL2
    Conserved Domains (1) summary
    PHA03247
    Location:8231182
    PHA03247; large tegument protein UL36; Provisional