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Txndc15 thioredoxin domain containing 15 [ Mus musculus (house mouse) ]

Gene ID: 69672, updated on 5-Mar-2024

Summary

Official Symbol
Txndc15provided by MGI
Official Full Name
thioredoxin domain containing 15provided by MGI
Primary source
MGI:MGI:1916922
See related
Ensembl:ENSMUSG00000021497 AllianceGenome:MGI:1916922
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UNQ335; C5orf14; 2310047H23Rik
Summary
Involved in cilium assembly and positive regulation of smoothened signaling pathway. Located in cilium. Orthologous to human TXNDC15 (thioredoxin domain containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 32.5), liver adult (RPKM 30.0) and 28 other tissues See more
Orthologs
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Genomic context

See Txndc15 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55862463..55874040)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55714650..55726227)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 46 Neighboring gene RIKEN cDNA B230219D22 gene Neighboring gene STARR-seq mESC enhancer starr_34621 Neighboring gene pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 Neighboring gene RIKEN cDNA 4930451E10 gene Neighboring gene STARR-seq mESC enhancer starr_34625 Neighboring gene cation channel, sperm associated 3 Neighboring gene STARR-seq mESC enhancer starr_34626

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thioredoxin domain-containing protein 15
Names
disulfide isomerase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175150.3NP_780359.2  thioredoxin domain-containing protein 15 precursor

    See identical proteins and their annotated locations for NP_780359.2

    Status: PROVISIONAL

    Source sequence(s)
    BC062180
    Consensus CDS
    CCDS26553.1
    UniProtKB/Swiss-Prot
    Q52KM6, Q6P6J9, Q8BV80, Q8K319
    Related
    ENSMUSP00000021959.10, ENSMUST00000021959.11
    Conserved Domains (1) summary
    cd02999
    Location:172275
    PDI_a_ERp44_like; PDIa family, endoplasmic reticulum protein 44 (ERp44)-like subfamily; composed of uncharacterized PDI-like eukaryotic proteins containing only one redox active TRX (a) domain with a CXXS motif, similar to ERp44. CXXS is still a redox active motif; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55862463..55874040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)