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TCP11 t-complex 11 [ Homo sapiens (human) ]

Gene ID: 6954, updated on 13-Mar-2020

Summary

Official Symbol
TCP11provided by HGNC
Official Full Name
t-complex 11provided by HGNC
Primary source
HGNC:HGNC:11658
See related
Ensembl:ENSG00000124678 MIM:186982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPPR; D6S230E
Expression
Restricted expression toward testis (RPKM 154.9) See more
Orthologs

Genomic context

See TCP11 in Genome Data Viewer
Location:
6p21.31
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (35118064..35141410, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35085848..35109187, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene UHRF1 binding protein 1 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 11 Neighboring gene uncharacterized LOC112267955 Neighboring gene uncharacterized LOC101929285 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0229, MGC111103

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
T-complex protein 11 homolog
Names
fertilization-promoting peptide receptor
t-complex 11 (a murine tcp homolog)
t-complex 11 homolog
t-complex 11, testis-specific
testis secretory sperm-binding protein Li 222n

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261817.2NP_001248746.2  T-complex protein 11 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL138721
    Consensus CDS
    CCDS59018.1
    Related
    ENSP00000404479.3, ENST00000444780.7
    Conserved Domains (1) summary
    pfam05794
    Location:53482
    Tcp11; T-complex protein 11
  2. NM_001261818.1NP_001248747.1  T-complex protein 11 homolog isoform 4

    See identical proteins and their annotated locations for NP_001248747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AF536533, AK301975, BF507838, DC396535
    Consensus CDS
    CCDS59017.1
    UniProtKB/Swiss-Prot
    Q8WWU5
    Related
    ENSP00000363085.4, ENST00000373974.8
    Conserved Domains (1) summary
    pfam05794
    Location:29451
    Tcp11; T-complex protein 11
  3. NM_001261819.1NP_001248748.1  T-complex protein 11 homolog isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AF260330, AK302022, BF507838, DC396535
    Consensus CDS
    CCDS59016.1
    UniProtKB/Swiss-Prot
    Q8WWU5
    Related
    ENSP00000402816.2, ENST00000412155.6
    Conserved Domains (1) summary
    pfam05794
    Location:24446
    Tcp11; T-complex protein 11
  4. NM_001261820.1NP_001248749.1  T-complex protein 11 homolog isoform 6

    See identical proteins and their annotated locations for NP_001248749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, includes an alternate internal exon in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (6), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF536532, AF536533, BF507838, DC396535
    Consensus CDS
    CCDS59015.1
    UniProtKB/Swiss-Prot
    Q8WWU5
    Related
    ENSP00000478603.1, ENST00000611141.4
    Conserved Domains (1) summary
    pfam05794
    Location:1424
    Tcp11; T-complex protein 11
  5. NM_001261821.1NP_001248750.1  T-complex protein 11 homolog isoform 6

    See identical proteins and their annotated locations for NP_001248750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences, including the use of a downstream, in-frame start codon, compared to variant 1. Variants 6 and 7 encode the same isoform (6), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF536533, BC090050, BF507838, DC396535
    Consensus CDS
    CCDS59015.1
    UniProtKB/Swiss-Prot
    Q8WWU5
    Conserved Domains (1) summary
    pfam05794
    Location:1424
    Tcp11; T-complex protein 11
  6. NM_001366323.1NP_001353252.1  T-complex protein 11 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Related
    ENSP00000415320.2, ENST00000418521.6
    Conserved Domains (1) summary
    pfam05794
    Location:1424
    Tcp11; T-complex protein 11
  7. NM_001366324.1NP_001353253.1  T-complex protein 11 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:15425
    Tcp11; T-complex protein 11
  8. NM_001366325.1NP_001353254.1  T-complex protein 11 homolog isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL138721
  9. NM_001366326.1NP_001353255.1  T-complex protein 11 homolog isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL138721
  10. NM_001366327.1NP_001353256.1  T-complex protein 11 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:1346
    Tcp11; T-complex protein 11
  11. NM_001366328.1NP_001353257.1  T-complex protein 11 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:1346
    Tcp11; T-complex protein 11
  12. NM_001366329.1NP_001353258.1  T-complex protein 11 homolog isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Conserved Domains (1) summary
    pfam05794
    Location:1346
    Tcp11; T-complex protein 11
  13. NM_001366330.1NP_001353259.1  T-complex protein 11 homolog isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL138721
  14. NM_001366331.1NP_001353260.1  T-complex protein 11 homolog isoform 11

    Status: VALIDATED

    Source sequence(s)
    AL138721
  15. NM_001366332.1NP_001353261.1  T-complex protein 11 homolog isoform 12

    Status: VALIDATED

    Source sequence(s)
    AL138721
    Related
    ENSP00000422105.1, ENST00000502480.5
  16. NM_001370687.1NP_001357616.1  T-complex protein 11 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL138721
    Consensus CDS
    CCDS47413.1
    Related
    ENSP00000308708.6, ENST00000311875.11
    Conserved Domains (1) summary
    pfam05794
    Location:58487
    Tcp11; T-complex protein 11
  17. NM_018679.5NP_061149.1  T-complex protein 11 homolog isoform 2

    See identical proteins and their annotated locations for NP_061149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, including the use of an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF536533, BF507838, DC396535
    Consensus CDS
    CCDS4799.1
    UniProtKB/Swiss-Prot
    Q8WWU5
    Related
    ENSP00000244645.3, ENST00000244645.7
    Conserved Domains (1) summary
    pfam05794
    Location:15425
    Tcp11; T-complex protein 11

RNA

  1. NR_158873.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL138721
  2. NR_158874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL138721

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    35118064..35141410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514832.1XP_011513134.1  T-complex protein 11 homolog isoform X2

    See identical proteins and their annotated locations for XP_011513134.1

    Conserved Domains (1) summary
    pfam05794
    Location:1346
    Tcp11; T-complex protein 11
  2. XM_011514830.2XP_011513132.2  T-complex protein 11 homolog isoform X1

    Conserved Domains (1) summary
    pfam05794
    Location:71439
    Tcp11; T-complex protein 11
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