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Wdfy1 WD repeat and FYVE domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69368, updated on 13-Dec-2022

Summary

Official Symbol
Wdfy1provided by MGI
Official Full Name
WD repeat and FYVE domain containing 1provided by MGI
Primary source
MGI:MGI:1916618
See related
Ensembl:ENSMUSG00000073643 AllianceGenome:MGI:1916618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jr1; WDF1; FENS-1; ZFYVE17; mKIAA1435; 1700013B03Rik; 1700120F24Rik
Summary
Predicted to enable 1-phosphatidylinositol binding activity. Involved in positive regulation of toll-like receptor 3 signaling pathway and positive regulation of toll-like receptor 4 signaling pathway. Located in early endosome. Is expressed in extraembryonic component; placenta; and skin. Orthologous to human WDFY1 (WD repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 34.1), whole brain E14.5 (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See Wdfy1 in Genome Data Viewer
Location:
1; 1 C4
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (79679979..79753764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (79702262..79776143, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24160 Neighboring gene adaptor-related protein complex AP-1, sigma 3 Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene predicted gene, 39666 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1435

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat and FYVE domain-containing protein 1
Names
WD40 and FYVE domain containing 1
WD40- and FYVE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111279.1NP_001104749.1  WD repeat and FYVE domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001104749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC083910, AK007215, AK159710, AK165554, AK220391, BQ031098
    Consensus CDS
    CCDS48296.1
    UniProtKB/Swiss-Prot
    E9Q4P1, Q5DTX9
    UniProtKB/TrEMBL
    A0A6P5Q5M2, A0A8C6MXD0
    Related
    ENSMUSP00000109140.2, ENSMUST00000113512.8
    Conserved Domains (3) summary
    cd15756
    Location:279354
    FYVE_WDFY1; FYVE domain found in WD40 repeat and FYVE domain-containing protein 1 (WDFY1) and similar proteins
    sd00039
    Location:2867
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:16272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_027057.3NP_081333.1  WD repeat and FYVE domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_081333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons and uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK005937, AK007215, BE197290
    Consensus CDS
    CCDS15090.1
    UniProtKB/TrEMBL
    Q9DAD3
    Related
    ENSMUSP00000040224.8, ENSMUST00000048820.14
    Conserved Domains (2) summary
    sd00039
    Location:2764
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:20138
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    79679979..79753764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153456.1XP_036009349.1  WD repeat and FYVE domain-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q5DTX9
    UniProtKB/TrEMBL
    A0A6P5Q5M2, A0A8C6MXD0
    Conserved Domains (3) summary
    cd15756
    Location:279354
    FYVE_WDFY1; FYVE domain found in WD40 repeat and FYVE domain-containing protein 1 (WDFY1) and similar proteins
    sd00039
    Location:2867
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:16272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006496543.3XP_006496606.1  WD repeat and FYVE domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    sd00039
    Location:1451
    7WD40; WD40 repeat [structural motif]
    cl28890
    Location:176251
    FYVE_like_SF; FYVE domain like superfamily
    cl29593
    Location:4169
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_030242794.1XP_030098654.1  WD repeat and FYVE domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:2764
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:16207
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_030242799.1XP_030098659.1  WD repeat and FYVE domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:2764
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:16207
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_017322387.1XP_017177876.1  WD repeat and FYVE domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:2764
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:16207
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_030242801.1XP_030098661.1  WD repeat and FYVE domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q9DAD3
    Conserved Domains (2) summary
    sd00039
    Location:2764
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:20138
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001785590.2 RNA Sequence

    Related
    ENSMUST00000113513.8