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Lrrc51 leucine rich repeat containing 51 [ Mus musculus (house mouse) ]

Gene ID: 69358, updated on 26-Sep-2022

Summary

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Official Symbol
Lrrc51provided by MGI
Official Full Name
leucine rich repeat containing 51provided by MGI
Primary source
MGI:MGI:1916608
See related
Ensembl:ENSMUSG00000064307 AllianceGenome:MGI:1916608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrtomt; 1700008D07Rik
Summary
Predicted to be located in cytoplasm. Is expressed in brain; nasal cavity respiratory epithelium; parathyroid gland; respiratory system; and testis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 271.1) and genital fat pad adult (RPKM 12.3) See more
Orthologs
all
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Genomic context

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See Lrrc51 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101562196..101583126, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101912989..101933918, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex C subunit 15 Neighboring gene transmembrane O-methyltransferase Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans. Ahmed ZM, et al. Nat Genet, 2008 Nov. PMID 18953341, Free PMC Article
  2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 51
NP_001156445.1
NP_001156446.1
NP_001344513.1
NP_081329.1
XP_006508246.1
XP_011240195.1
XP_011240196.1
XP_011240197.1
XP_011240198.1
XP_030098830.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162973.1 → NP_001156445.1  leucine-rich repeat-containing protein 51 isoform 1

    See identical proteins and their annotated locations for NP_001156445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS52332.1
    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Related
    ENSMUSP00000102579.2, ENSMUST00000106966.8
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

  2. NM_001162974.2 → NP_001156446.1  leucine-rich repeat-containing protein 51 isoform 2

    See identical proteins and their annotated locations for NP_001156446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS52331.1
    UniProtKB/Swiss-Prot
    Q9DAK8
    Related
    ENSMUSP00000102576.2, ENSMUST00000106963.2
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:85 → 146
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. NM_001357584.1 → NP_001344513.1  leucine-rich repeat-containing protein 51 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS52332.1
    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Related
    ENSMUSP00000102581.2, ENSMUST00000106968.8
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

  4. NM_027053.1 → NP_081329.1  leucine-rich repeat-containing protein 51 isoform 1

    See identical proteins and their annotated locations for NP_081329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC167240, AK005758
    Consensus CDS
    CCDS52332.1
    UniProtKB/Swiss-Prot
    Q9DAK8
    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Related
    ENSMUSP00000077543.4, ENSMUST00000078448.11
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101562196..101583126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508183.5 → XP_006508246.1  leucine-rich repeat-containing protein 51 isoform X1

    See identical proteins and their annotated locations for XP_006508246.1

    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

  2. XM_011241894.4 → XP_011240196.1  leucine-rich repeat-containing protein 51 isoform X1

    See identical proteins and their annotated locations for XP_011240196.1

    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

  3. XM_011241893.4 → XP_011240195.1  leucine-rich repeat-containing protein 51 isoform X1

    See identical proteins and their annotated locations for XP_011240195.1

    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

  4. XM_011241895.4 → XP_011240197.1  leucine-rich repeat-containing protein 51 isoform X1

    See identical proteins and their annotated locations for XP_011240197.1

    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat

  5. XM_030242970.1 → XP_030098830.1  leucine-rich repeat-containing protein 51 isoform X2

    Related
    ENSMUSP00000095838.3, ENSMUST00000098236.9
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:85 → 146
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  6. XM_011241896.2 → XP_011240198.1  leucine-rich repeat-containing protein 51 isoform X1

    See identical proteins and their annotated locations for XP_011240198.1

    UniProtKB/TrEMBL
    A0A8C6IB83, G5E8I1
    Conserved Domains (2) summary
    sd00033
    Location:52 → 80
    LRR_RI; leucine-rich repeat [structural motif]
    pfam14580
    Location:89 → 173
    LRR_9; Leucine-rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAK8.1 GenPept UniProtKB/Swiss-Prot:Q9DAK8

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