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Ddah1 dimethylarginine dimethylaminohydrolase 1 [ Mus musculus (house mouse) ]

Gene ID: 69219, updated on 2-Nov-2024

Summary

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Official Symbol
Ddah1provided by MGI
Official Full Name
dimethylarginine dimethylaminohydrolase 1provided by MGI
Primary source
MGI:MGI:1916469
See related
Ensembl:ENSMUSG00000028194 AllianceGenome:MGI:1916469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410006N07Rik; 2510015N06Rik
Summary
Enables dimethylargininase activity. Involved in positive regulation of nitric oxide biosynthetic process and regulation of systemic arterial blood pressure. Located in mitochondrion. Is expressed in several structures, including brain; cardiovascular system; future prosencephalon; retina; and spinal cord. Human ortholog(s) of this gene implicated in cardiovascular system disease; coronary artery disease; and hypertension. Orthologous to human DDAH1 (dimethylarginine dimethylaminohydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 50.5), liver adult (RPKM 34.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Ddah1 in Genome Data Viewer
Location:
3 H2; 3 70.63 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145464447..145600032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145758692..145894277)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17501 Neighboring gene cellular communication network factor 1 Neighboring gene STARR-seq mESC enhancer starr_09202 Neighboring gene STARR-seq mESC enhancer starr_09203 Neighboring gene STARR-seq mESC enhancer starr_09204 Neighboring gene STARR-seq mESC enhancer starr_09205 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187 Neighboring gene STARR-positive B cell enhancer mm9_chr3:145568448-145568748 Neighboring gene STARR-positive B cell enhancer ABC_E35 Neighboring gene STARR-positive B cell enhancer ABC_E6142 Neighboring gene STARR-positive B cell enhancer ABC_E11228 Neighboring gene RIKEN cDNA 2410004B18 gene Neighboring gene STARR-positive B cell enhancer ABC_E336 Neighboring gene STARR-positive B cell enhancer ABC_E9228 Neighboring gene B cell leukemia/lymphoma 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1. Wang Y, et al. iScience, 2021 Oct 22. PMID 34703990, Free PMC Article
  2. Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice. Hu W, et al. Mol Med Rep, 2020 Jan. PMID 31746378
  3. Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia. Bakr A, et al. Am J Respir Cell Mol Biol, 2013 Sep. PMID 23642043, Free PMC Article
  4. Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice. Shi X, et al. Biosci Trends, 2020 May 21. PMID 32238672
  5. Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice. Hannemann J, et al. Front Physiol, 2020. PMID 33281630, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
    Title: DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis.
  2. Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism.
    Title: Knock-out of the critical nitric oxide synthase regulator DDAH1 in mice impacts amphetamine sensitivity and dopamine metabolism.
  3. Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress.
    Title: Dimethylarginine dimethylaminohydrolase 1 protects PM(2.5) exposure-induced lung injury in mice by repressing inflammation and oxidative stress.
  4. Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
    Title: Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.
  5. Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling.
    Title: Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II-induced cardiac hypertrophy and vascular remodeling.
  6. Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
    Title: Dimethylarginine dimethylaminohydrolase-1 contributes to exercise-induced cardiac angiogenesis in mice.
  7. Blueberry anthocyaninenriched extract ameliorates transverse aortic constrictioninduced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
    Title: Blueberry anthocyanin‑enriched extract ameliorates transverse aortic constriction‑induced myocardial dysfunction via the DDAH1/ADMA/NO signaling pathway in mice.
  8. Fluid reabsorption in the proximal tubule is reduced by tubular ADMA or by blocking its metabolism by DDAH-1.
    Title: Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1.
  9. DDAH1 in cardiomyocytes plays a vital role in attenuating left ventricular remodeling after acute myocardial infarction by regulating intracellular ROS levels and apoptosis sensitivity via a SOD2-dependent pathway.
    Title: Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis.
  10. Cardiomyocyte DDAH1 activity is dispensable for cardiac function under basal conditions, but plays an important role in attenuating cardiac hypertrophy and ventricular remodeling under stress conditions, possibly through locally confined regulation of subcellular ADMA and NO signaling.
    Title: Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amino acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
  
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
  
enables dimethylargininase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dimethylargininase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables dimethylargininase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables dimethylargininase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in arginine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in citrulline metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in citrulline metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in citrulline metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein nitrosylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Names
DDAH-1
DDAHI
dimethylargininase-1
NP_081269.1
XP_011238523.1
XP_017175201.1
XP_030108663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026993.3 → NP_081269.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

    See identical proteins and their annotated locations for NP_081269.1

    Status: VALIDATED

    Source sequence(s)
    AK010970, AK148907, AK149185
    Consensus CDS
    CCDS17896.1
    UniProtKB/Swiss-Prot
    Q3UF65, Q9CWS0
    Related
    ENSMUSP00000029845.9, ENSMUST00000029845.15
    Conserved Domains (1) summary
    cl19186
    Location:11 → 276
    Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145464447..145600032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240221.4 → XP_011238523.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2

    See identical proteins and their annotated locations for XP_011238523.1

    UniProtKB/TrEMBL
    D3YU15, Q3UF01
    Conserved Domains (1) summary
    cl19186
    Location:3 → 173
    Amidinotransf; Amidinotransferase

  2. XM_030252803.1 → XP_030108663.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2

    UniProtKB/TrEMBL
    D3YU15, Q3UF01
    Related
    ENSMUSP00000112747.2, ENSMUST00000120310.2
    Conserved Domains (1) summary
    cl19186
    Location:3 → 173
    Amidinotransf; Amidinotransferase

  3. XM_017319712.2 → XP_017175201.1  N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X1

    UniProtKB/TrEMBL
    Q3UF01
    Conserved Domains (1) summary
    cl19186
    Location:23 → 193
    Amidinotransf; Amidinotransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWS0.3 GenPept UniProtKB/Swiss-Prot:Q9CWS0

Gene LinkOut

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