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Gsdmd gasdermin D [ Mus musculus (house mouse) ]

Gene ID: 69146, updated on 22-Jan-2023

Summary

Official Symbol
Gsdmdprovided by MGI
Official Full Name
gasdermin Dprovided by MGI
Primary source
MGI:MGI:1916396
See related
Ensembl:ENSMUSG00000022575 AllianceGenome:MGI:1916396
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DF5L; M2-4; Dfna5l; GsdmD-1; Gsdmdc1; 1810036L03Rik
Summary
Enables phospholipid binding activity and wide pore channel activity. Involved in several processes, including defense response to bacterium; positive regulation of interleukin-1 beta production; and protein-containing complex assembly. Acts upstream of or within cellular response to extracellular stimulus. Located in cytosol; extracellular space; and plasma membrane. Part of NLRP3 inflammasome complex. Is expressed in several structures, including gut; liver; lung; metanephros; and spleen. Orthologous to human GSDMD (gasdermin D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 65.8), small intestine adult (RPKM 51.8) and 17 other tissues See more
Orthologs
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Genomic context

See Gsdmd in Genome Data Viewer
Location:
15; 15 D3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75733990..75739257)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75862144..75867408)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53897 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cardiolipin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables wide pore channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in pore complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-18 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pyroptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of inflammasome complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gasdermin-D
Names
gasdermin domain containing 1
gasdermin domain-containing protein 1
gasderminD-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026960.4NP_081236.1  gasdermin-D

    See identical proteins and their annotated locations for NP_081236.1

    Status: PROVISIONAL

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27551.1
    UniProtKB/Swiss-Prot
    Q3TBD9, Q9D8T2
    UniProtKB/TrEMBL
    A0A679AXP3
    Related
    ENSMUSP00000023238.5, ENSMUST00000023238.6
    Conserved Domains (2) summary
    pfam04598
    Location:4243
    Gasdermin; Gasdermin family
    pfam17708
    Location:287459
    Gasdermin_C; Gasdermin PUB domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75733990..75739257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521343.5XP_006521406.1  gasdermin-D isoform X1

    Conserved Domains (2) summary
    pfam04598
    Location:18123
    Gasdermin; Gasdermin family
    pfam17708
    Location:167339
    Gasdermin_C; Gasdermin PUB domain

RNA

  1. XR_004938868.1 RNA Sequence

  2. XR_384037.5 RNA Sequence