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TBCD tubulin folding cofactor D [ Homo sapiens (human) ]

Gene ID: 6904, updated on 20-Dec-2019

Summary

Official Symbol
TBCDprovided by HGNC
Official Full Name
tubulin folding cofactor Dprovided by HGNC
Primary source
HGNC:HGNC:11581
See related
Ensembl:ENSG00000141556 MIM:604649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
tfcD; PEBAT; SSD-1
Summary
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 5.2), thyroid (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See TBCD in Genome Data Viewer
Location:
17q25.3
Exon count:
61
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82752048..82945914)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80709938..80901062)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene fructosamine 3 kinase related protein Neighboring gene Sharpr-MPRA regulatory region 591 Neighboring gene fructosamine 3 kinase Neighboring gene zinc finger protein 750 Neighboring gene TBCD intron CAGE-defined B cell enhancer Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 Neighboring gene uncharacterized LOC107987251 Neighboring gene meteorin like, glial cell differentiation regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
post-chaperonin tubulin folding pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding IDA
Inferred from Direct Assay
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
PubMed 
tubulin complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tubulin-specific chaperone D
Names
beta-tubulin cofactor D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011721.1 RefSeqGene

    Range
    5001..196123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005993.5NP_005984.3  tubulin-specific chaperone D

    See identical proteins and their annotated locations for NP_005984.3

    Status: REVIEWED

    Source sequence(s)
    AC130371, BC003094, BC012824, BI464569
    Consensus CDS
    CCDS45818.1
    UniProtKB/Swiss-Prot
    Q9BTW9
    Related
    ENSP00000347719.4, ENST00000355528.9
    Conserved Domains (2) summary
    pfam12612
    Location:8971087
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:63914
    TFCD_C; Tubulin folding cofactor D C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82752048..82945914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256396.4XP_005256453.1  tubulin-specific chaperone D isoform X1

    Related
    ENSP00000440671.2, ENST00000539345.6
    Conserved Domains (2) summary
    pfam12612
    Location:8801070
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:342897
    TFCD_C; Tubulin folding cofactor D C terminal
  2. XM_006722290.2XP_006722353.1  tubulin-specific chaperone D isoform X2

    Conserved Domains (2) summary
    pfam12612
    Location:8701060
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:63887
    TFCD_C; Tubulin folding cofactor D C terminal
  3. XM_011523590.1XP_011521892.1  tubulin-specific chaperone D isoform X6

    Conserved Domains (2) summary
    pfam12612
    Location:778968
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:63795
    TFCD_C; Tubulin folding cofactor D C terminal
  4. XM_017024988.1XP_016880477.1  tubulin-specific chaperone D isoform X12

  5. XM_017024987.1XP_016880476.1  tubulin-specific chaperone D isoform X4

  6. XM_011523591.2XP_011521893.1  tubulin-specific chaperone D isoform X3

    Conserved Domains (2) summary
    pfam12612
    Location:777967
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:239794
    TFCD_C; Tubulin folding cofactor D C terminal
  7. XM_011523589.2XP_011521891.1  tubulin-specific chaperone D isoform X5

    Conserved Domains (2) summary
    pfam12612
    Location:782972
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:244799
    TFCD_C; Tubulin folding cofactor D C terminal
  8. XM_011523593.2XP_011521895.1  tubulin-specific chaperone D isoform X7

    Conserved Domains (2) summary
    pfam12612
    Location:646836
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:108663
    TFCD_C; Tubulin folding cofactor D C terminal
  9. XM_017024990.2XP_016880479.1  tubulin-specific chaperone D isoform X17

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  10. XM_024450901.1XP_024306669.1  tubulin-specific chaperone D isoform X17

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  11. XM_006722291.4XP_006722354.1  tubulin-specific chaperone D isoform X10

    Conserved Domains (2) summary
    pfam12612
    Location:465655
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:4482
    TFCD_C; Tubulin folding cofactor D C terminal
  12. XM_024450902.1XP_024306670.1  tubulin-specific chaperone D isoform X17

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  13. XM_005256399.5XP_005256456.1  tubulin-specific chaperone D isoform X9

    Conserved Domains (2) summary
    pfam12612
    Location:469659
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:12486
    TFCD_C; Tubulin folding cofactor D C terminal
  14. XM_024450900.1XP_024306668.1  tubulin-specific chaperone D isoform X17

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  15. XM_024450899.1XP_024306667.1  tubulin-specific chaperone D isoform X17

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  16. XM_005256404.4XP_005256461.1  tubulin-specific chaperone D isoform X17

    See identical proteins and their annotated locations for XP_005256461.1

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  17. XM_011523595.3XP_011521897.1  tubulin-specific chaperone D isoform X11

    Conserved Domains (2) summary
    pfam12612
    Location:462652
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:49479
    TFCD_C; Tubulin folding cofactor D C terminal
  18. XM_011523594.2XP_011521896.1  tubulin-specific chaperone D isoform X8

    Conserved Domains (2) summary
    pfam12612
    Location:473663
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:70490
    TFCD_C; Tubulin folding cofactor D C terminal
  19. XM_011523600.3XP_011521902.1  tubulin-specific chaperone D isoform X17

    See identical proteins and their annotated locations for XP_011521902.1

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  20. XM_006722292.3XP_006722355.1  tubulin-specific chaperone D isoform X17

    See identical proteins and their annotated locations for XP_006722355.1

    Conserved Domains (2) summary
    pfam12612
    Location:338525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:290352
    TFCD_C; Tubulin folding cofactor D C terminal
  21. XM_011523597.2XP_011521899.1  tubulin-specific chaperone D isoform X13

    Conserved Domains (2) summary
    pfam12612
    Location:384574
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:339401
    TFCD_C; Tubulin folding cofactor D C terminal
  22. XM_011523599.2XP_011521901.1  tubulin-specific chaperone D isoform X15

    Conserved Domains (2) summary
    pfam12612
    Location:381571
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:336398
    TFCD_C; Tubulin folding cofactor D C terminal
  23. XM_011523598.1XP_011521900.1  tubulin-specific chaperone D isoform X14

    Conserved Domains (2) summary
    pfam12612
    Location:383573
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:338400
    TFCD_C; Tubulin folding cofactor D C terminal
  24. XM_017024989.1XP_016880478.1  tubulin-specific chaperone D isoform X16

RNA

  1. XR_430033.2 RNA Sequence

  2. XR_001752600.1 RNA Sequence

  3. XR_001752598.1 RNA Sequence

  4. XR_001752597.1 RNA Sequence

  5. XR_001752599.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187612.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    155511..177989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033052.1: Suppressed sequence

    Description
    NM_001033052.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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