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TBCC tubulin folding cofactor C [ Homo sapiens (human) ]

Gene ID: 6903, updated on 11-Jun-2021

Summary

Official Symbol
TBCCprovided by HGNC
Official Full Name
tubulin folding cofactor Cprovided by HGNC
Primary source
HGNC:HGNC:11580
See related
Ensembl:ENSG00000124659 MIM:602971
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFC
Summary
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See TBCC in Genome Data Viewer
Location:
6p21.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (42744498..42746103, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42712236..42713841, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene peripherin 2 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 3 Neighboring gene BICRA like chromatin remodeling complex associated protein Neighboring gene uncharacterized LOC401261 Neighboring gene ribosomal protein L7 like 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chaperone binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in post-chaperonin tubulin folding pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding TAS
Traceable Author Statement
more info
PubMed 
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in microtubule TAS
Traceable Author Statement
more info
PubMed 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulin-specific chaperone C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003192.3NP_003183.2  tubulin-specific chaperone C

    Status: REVIEWED

    Source sequence(s)
    AL353716
    Consensus CDS
    CCDS4872.1
    Related
    ENSP00000361967.1, ENST00000372876.2
    Conserved Domains (2) summary
    pfam07986
    Location:204321
    TBCC; Tubulin binding cofactor C
    pfam16752
    Location:29135
    TBCC_N; Tubulin-specific chaperone C N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    42744498..42746103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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