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Prpf31 pre-mRNA processing factor 31 [ Mus musculus (house mouse) ]

Gene ID: 68988, updated on 1-Mar-2024

Summary

Official Symbol
Prpf31provided by MGI
Official Full Name
pre-mRNA processing factor 31provided by MGI
Primary source
MGI:MGI:1916238
See related
Ensembl:ENSMUSG00000008373 AllianceGenome:MGI:1916238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RP11; PRP31; 1500019O16Rik; 2810404O06Rik
Summary
Predicted to enable identical protein binding activity; snRNA binding activity; and snRNP binding activity. Predicted to be involved in ribonucleoprotein complex localization and spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of nucleus. Is expressed in embryo. Used to study retinitis pigmentosa 11. Human ortholog(s) of this gene implicated in retinitis pigmentosa 11. Orthologous to human PRPF31 (pre-mRNA processing factor 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 27.4), CNS E14 (RPKM 16.8) and 28 other tissues See more
Orthologs
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Genomic context

See Prpf31 in Genome Data Viewer
Location:
7 A1; 7 2.09 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3632984..3645484)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3629985..3642485)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene TCF3 (E2A) fusion partner Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:3581200-3581309 Neighboring gene STARR-positive B cell enhancer ABC_E2811 Neighboring gene predicted gene 15927 Neighboring gene STARR-seq mESC enhancer starr_17914 Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene microRNA 3572 Neighboring gene STARR-positive B cell enhancer ABC_E1077 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables U4 snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables U4atac snRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables snRNP binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in ribonucleoprotein complex localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U4 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U4 snRNP ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of U4atac snRNP ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
U4/U6 small nuclear ribonucleoprotein Prp31
Names
PRP31 pre-mRNA processing factor 31 homolog
U4/U6 snRNP 61 kDa protein
protein 61K

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159714.1NP_001153186.1  U4/U6 small nuclear ribonucleoprotein Prp31 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform 1.
    Source sequence(s)
    AC171680, BB839183, BC061461
    Consensus CDS
    CCDS51965.1
    UniProtKB/Swiss-Prot
    Q8CCF0
    Related
    ENSMUSP00000136031.2, ENSMUST00000179769.8
    Conserved Domains (1) summary
    COG1498
    Location:77340
    SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
  2. NM_027328.4NP_081604.3  U4/U6 small nuclear ribonucleoprotein Prp31 isoform 1

    See identical proteins and their annotated locations for NP_081604.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC171680, AK033283, AK051260, BB839183
    Consensus CDS
    CCDS39729.1
    UniProtKB/Swiss-Prot
    E9QPM6, Q6P7X2, Q8BQ91, Q8C8U4, Q8C8V5, Q8CCF0, Q8CCG6, Q8CF52, Q8VBW3
    Related
    ENSMUSP00000008517.7, ENSMUST00000008517.13
    Conserved Domains (2) summary
    pfam01798
    Location:100330
    Nop; snoRNA binding domain, fibrillarin
    pfam09785
    Location:337465
    Prp31_C; Prp31 C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3632984..3645484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)