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Tatdn3 TatD DNase domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 68972, updated on 26-Sep-2022

Summary

Official Symbol
Tatdn3provided by MGI
Official Full Name
TatD DNase domain containing 3provided by MGI
Primary source
MGI:MGI:1916222
See related
Ensembl:ENSMUSG00000026632 AllianceGenome:MGI:1916222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500010M24Rik
Summary
Predicted to enable metal ion binding activity and nuclease activity. Located in mitochondrion. Orthologous to human TATDN3 (TatD DNase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
Orthologs
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Genomic context

See Tatdn3 in Genome Data Viewer
Location:
1; 1 H6
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190778023..190795373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191045826..191063075, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene feline leukemia virus subgroup C cellular receptor 1 Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene spermatogenesis associated 45 Neighboring gene NSL1, MIS12 kinetochore complex component Neighboring gene basic leucine zipper transcription factor, ATF-like 3 Neighboring gene predicted gene, 46178

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative deoxyribonuclease TATDN3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163421.1NP_001156893.1  putative deoxyribonuclease TATDN3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS48486.1
    UniProtKB/TrEMBL
    D3Z0V5
    Related
    ENSMUSP00000106516.2, ENSMUST00000110891.8
    Conserved Domains (1) summary
    cd01310
    Location:5223
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  2. NM_001163422.1NP_001156894.1  putative deoxyribonuclease TATDN3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS48484.1
    UniProtKB/Swiss-Prot
    Q3U1C6
    Related
    ENSMUSP00000082773.6, ENSMUST00000085633.12
    Conserved Domains (1) summary
    cl00281
    Location:5158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  3. NM_001357166.1NP_001344095.1  putative deoxyribonuclease TATDN3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS87944.1
    UniProtKB/TrEMBL
    D3YXH9
    Related
    ENSMUSP00000027945.6, ENSMUST00000027945.6
    Conserved Domains (1) summary
    cd01310
    Location:5261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.
  4. NM_026895.1NP_081171.1  putative deoxyribonuclease TATDN3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS48485.1
    UniProtKB/TrEMBL
    E9QL22
    Related
    ENSMUSP00000106518.4, ENSMUST00000110893.10
    Conserved Domains (2) summary
    COG1099
    Location:6262
    COG1099; Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]
    cd01310
    Location:5262
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190778023..190795373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497204.5XP_006497267.1  putative deoxyribonuclease TATDN3 isoform X1

    Conserved Domains (1) summary
    cl00281
    Location:51209
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...