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Phkg2 phosphorylase kinase, gamma 2 (testis) [ Mus musculus (house mouse) ]

Gene ID: 68961, updated on 1-Mar-2024

Summary

Official Symbol
Phkg2provided by MGI
Official Full Name
phosphorylase kinase, gamma 2 (testis)provided by MGI
Primary source
MGI:MGI:1916211
See related
Ensembl:ENSMUSG00000030815 AllianceGenome:MGI:1916211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500017I02Rik
Summary
Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and phosphorylase kinase activity. Predicted to be involved in glycogen metabolic process and protein phosphorylation. Predicted to act upstream of or within carbohydrate metabolic process and phosphorylation. Predicted to be located in cytosol. Predicted to be part of phosphorylase kinase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to human PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 599.3) and thymus adult (RPKM 26.5) See more
Orthologs
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Genomic context

See Phkg2 in Genome Data Viewer
Location:
7 F3; 7 69.6 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127169252..127182479)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127573345..127583307)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134716729-134716937 Neighboring gene STARR-positive B cell enhancer ABC_E6607 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphorylase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphorylase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of phosphorylase kinase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Names
PHK-gamma-LT
PHK-gamma-T
phosphorylase kinase subunit gamma-2
serine/threonine-protein kinase PHKG2
NP_001347670.1
NP_081164.2
XP_006508230.1
XP_006508231.1
XP_006508232.1
XP_030098816.1
XP_030098817.1
XP_030098818.1
XP_030098819.1
XP_036009301.1
XP_036009302.1
XP_036009303.1
XP_036009304.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360741.1NP_001347670.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction and lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122417
    Conserved Domains (1) summary
    cl21453
    Location:1182
    PKc_like; Protein Kinases, catalytic domain
  2. NM_026888.3NP_081164.2  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 1

    See identical proteins and their annotated locations for NP_081164.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA198694, AK005277, AK079680, BQ176174
    Consensus CDS
    CCDS21869.1
    UniProtKB/Swiss-Prot
    A6H632, Q9DB30
    Related
    ENSMUSP00000033086.2, ENSMUST00000033086.8
    Conserved Domains (1) summary
    cl21453
    Location:13291
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127169252..127182479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153408.1XP_036009301.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    UniProtKB/Swiss-Prot
    A6H632, Q9DB30
    Related
    ENSMUSP00000113533.2, ENSMUST00000121004.3
    Conserved Domains (1) summary
    cl21453
    Location:13291
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036153410.1XP_036009303.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1189
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006508167.4XP_006508230.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

    See identical proteins and their annotated locations for XP_006508230.1

    UniProtKB/Swiss-Prot
    A6H632, Q9DB30
    Conserved Domains (1) summary
    cl21453
    Location:13291
    PKc_like; Protein Kinases, catalytic domain
  4. XM_030242958.1XP_030098818.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1182
    PKc_like; Protein Kinases, catalytic domain
  5. XM_030242957.1XP_030098817.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1189
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036153411.1XP_036009304.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1189
    PKc_like; Protein Kinases, catalytic domain
  7. XM_006508168.3XP_006508231.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    See identical proteins and their annotated locations for XP_006508231.1

    Conserved Domains (1) summary
    cl21453
    Location:10194
    PKc_like; Protein Kinases, catalytic domain
  8. XM_030242956.1XP_030098816.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1189
    PKc_like; Protein Kinases, catalytic domain
  9. XM_006508169.4XP_006508232.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    See identical proteins and their annotated locations for XP_006508232.1

    Conserved Domains (1) summary
    cl21453
    Location:10194
    PKc_like; Protein Kinases, catalytic domain
  10. XM_036153409.1XP_036009302.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:10194
    PKc_like; Protein Kinases, catalytic domain
  11. XM_030242959.1XP_030098819.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1182
    PKc_like; Protein Kinases, catalytic domain