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Pygo2 pygopus 2 [ Mus musculus (house mouse) ]

Gene ID: 68911, updated on 21-Apr-2024

Summary

Official Symbol
Pygo2provided by MGI
Official Full Name
pygopus 2provided by MGI
Primary source
MGI:MGI:1916161
See related
Ensembl:ENSMUSG00000047824 AllianceGenome:MGI:1916161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190004M21Rik
Summary
Enables chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and spermatid nucleus differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Orthologous to human PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 22.5), ovary adult (RPKM 22.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
3 F1; 3 39.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89337521..89342438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89430114..89435131)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene CDC28 protein kinase 1b Neighboring gene src homology 2 domain-containing transforming protein C1 Neighboring gene STARR-positive B cell enhancer ABC_E2080 Neighboring gene STARR-positive B cell enhancer ABC_E9557 Neighboring gene pre B cell leukemia transcription factor interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6071 Neighboring gene STARR-positive B cell enhancer ABC_E2081 Neighboring gene phosphomevalonate kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anatomical structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatid development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in spermatid nucleus differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatid nucleus differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293763.2NP_001280692.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001280692.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
  2. NM_001293766.3NP_001280695.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001280695.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
  3. NM_001293767.2NP_001280696.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001280696.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
  4. NM_001293768.2NP_001280697.1  pygopus homolog 2 isoform a

    See identical proteins and their annotated locations for NP_001280697.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS79952.1
    UniProtKB/TrEMBL
    Q80V76
    Related
    ENSMUSP00000053672.5, ENSMUST00000060061.11
    Conserved Domains (1) summary
    cd15636
    Location:328381
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
  5. NM_001429109.1NP_001416038.1  pygopus homolog 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171273
  6. NM_001429110.1NP_001416039.1  pygopus homolog 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171273
  7. NM_026869.3NP_081145.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_081145.1

    Status: VALIDATED

    Source sequence(s)
    AI843615, AK132759
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Related
    ENSMUSP00000103036.2, ENSMUST00000107413.2
    Conserved Domains (2) summary
    PRK14959
    Location:135271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89337521..89342438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252785.1XP_030108645.1  pygopus homolog 2 isoform X1

    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
  2. XM_030252784.2XP_030108644.1  pygopus homolog 2 isoform X1

    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)