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Arhgap10 Rho GTPase activating protein 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688429, updated on 17-Aug-2024

Summary

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Official Symbol
Arhgap10provided by RGD
Official Full Name
Rho GTPase activating protein 10provided by RGD
Primary source
RGD:1588859
See related
EnsemblRapid:ENSRNOG00000013152 AllianceGenome:RGD:1588859
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Predicted to be active in cytosol. Orthologous to human ARHGAP10 (Rho GTPase activating protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 66.0), Heart (RPKM 58.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (47352783..47614532)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (30448572..30710315)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (34138978..34406593)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483343 Neighboring gene endothelin receptor type A Neighboring gene transmembrane protein 184C Neighboring gene protein arginine methyltransferase 9 Neighboring gene uncharacterized LOC134483344 Neighboring gene membrane-associated progesterone receptor component 1 pseudogene Neighboring gene uncharacterized LOC134483345 Neighboring gene nuclear receptor subfamily 3, group C, member 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134483346

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. Koeppel MA, et al. J Biol Chem, 2004 Dec 17. PMID 15471851
  2. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. Ren XR, et al. J Cell Biol, 2001 Mar 5. PMID 11238453, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109501.1 → NP_001102971.1  rho GTPase-activating protein 10

    See identical proteins and their annotated locations for NP_001102971.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IYL0, D4AB50
    Related
    ENSRNOP00000017867.7, ENSRNOT00000017867.7
    Conserved Domains (5) summary
    cd07635
    Location:19 → 225
    BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
    cd12065
    Location:732 → 785
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:367 → 569
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:269 → 367
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    47352783..47614532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097993.2 → XP_038953921.1  rho GTPase-activating protein 10 isoform X9

    Conserved Domains (2) summary
    cd01249
    Location:267 → 366
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_039097995.2 → XP_038953923.1  rho GTPase-activating protein 10 isoform X10

    Conserved Domains (2) summary
    cd01249
    Location:267 → 366
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_017601359.3 → XP_017456848.1  rho GTPase-activating protein 10 isoform X6

  4. XM_039097987.2 → XP_038953915.1  rho GTPase-activating protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADP2
    Conserved Domains (5) summary
    cd07635
    Location:19 → 225
    BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
    cd12065
    Location:744 → 797
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:554 → 691
    PHA03247; large tegument protein UL36; Provisional
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:367 → 544
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

  5. XM_039097986.2 → XP_038953914.1  rho GTPase-activating protein 10 isoform X1

    UniProtKB/TrEMBL
    D4AB50
    Conserved Domains (5) summary
    cd07635
    Location:19 → 225
    BAR_GRAF2; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
    cd12065
    Location:769 → 822
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:579 → 716
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:367 → 569
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

  6. XM_008772531.4 → XP_008770753.1  rho GTPase-activating protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A8K7, D4AB50
    Related
    ENSRNOP00000089391.1, ENSRNOT00000111579.2
    Conserved Domains (5) summary
    cd12065
    Location:681 → 734
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:367 → 569
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:269 → 367
    PH; PH domain
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_063278285.1 → XP_063134355.1  rho GTPase-activating protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZK44, A0A8I6ADP2
    Related
    ENSRNOP00000076625.1, ENSRNOT00000111331.2

  8. XM_039097988.2 → XP_038953916.1  rho GTPase-activating protein 10 isoform X5

    UniProtKB/TrEMBL
    D4AB50
    Conserved Domains (5) summary
    cd12065
    Location:666 → 719
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:476 → 613
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_063278286.1 → XP_063134356.1  rho GTPase-activating protein 10 isoform X5

    UniProtKB/TrEMBL
    D4AB50

  10. XM_039097992.1 → XP_038953920.1  rho GTPase-activating protein 10 isoform X5

    UniProtKB/TrEMBL
    D4AB50
    Conserved Domains (5) summary
    cd12065
    Location:666 → 719
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:476 → 613
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_063278287.1 → XP_063134357.1  rho GTPase-activating protein 10 isoform X7

    UniProtKB/TrEMBL
    D4AB50
    Related
    ENSRNOP00000109651.1, ENSRNOT00000129503.1

  12. XM_063278288.1 → XP_063134358.1  rho GTPase-activating protein 10 isoform X8

  13. XM_039097989.2 → XP_038953917.1  rho GTPase-activating protein 10 isoform X5

    UniProtKB/TrEMBL
    D4AB50
    Conserved Domains (5) summary
    cd12065
    Location:666 → 719
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:476 → 613
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  14. XM_039097991.2 → XP_038953919.1  rho GTPase-activating protein 10 isoform X5

    UniProtKB/TrEMBL
    D4AB50
    Conserved Domains (5) summary
    cd12065
    Location:666 → 719
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:476 → 613
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  15. XM_039097990.2 → XP_038953918.1  rho GTPase-activating protein 10 isoform X5

    UniProtKB/TrEMBL
    D4AB50
    Conserved Domains (5) summary
    cd12065
    Location:666 → 719
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    PHA03247
    Location:476 → 613
    PHA03247; large tegument protein UL36; Provisional
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_005496688.2 RNA Sequence

  2. XR_010060031.1 RNA Sequence

  3. XR_005496687.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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