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Rac3 Rac family small GTPase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 688319, updated on 18-Sep-2024

Summary

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Symbol
Rac3provided by RGD
Full Name
Rac family small GTPase 3provided by RGD
Primary source
RGD:1590052
See related
EnsemblRapid:ENSRNOG00000069600 AllianceGenome:RGD:1590052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activity and calcium-dependent protein binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; cell projection assembly; and positive regulation of cell adhesion. Predicted to act upstream of or within several processes, including GABAergic synaptic transmission; neuron development; and regulation of neuron maturation. Located in cytoskeleton; cytosol; and growth cone. Orthologous to human RAC3 (Rac family small GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 202.9), Liver (RPKM 67.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106501133..106503569)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106002808..106005243)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109903920..109906596)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centromere protein X Neighboring gene 60S ribosomal protein L36a-like Neighboring gene leucine rich repeat containing 45 Neighboring gene dicarbonyl and L-xylulose reductase Neighboring gene carbonyl reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. Donnelly SK, et al. J Cell Biol, 2017 Dec 4. PMID 29061650, Free PMC Article
  2. The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. Haataja L, et al. J Biol Chem, 2002 Mar 8. PMID 11756406
  3. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. De Langhe S, et al. Int J Mol Med, 2002 May. PMID 11956649
  4. Rac3-induced neuritogenesis requires binding to Neurabin I. Orioli D, et al. Mol Biol Cell, 2006 May. PMID 16525025, Free PMC Article
  5. WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome. White JJ, et al. Am J Hum Genet, 2018 Jan 4. PMID 29276006, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
    Title: Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebral cortex GABAergic interneuron development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of neuron maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
  
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related C3 botulinum toxin substrate 3
Names
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
NP_001385883.1
XP_063125945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398954.1 → NP_001385883.1  ras-related C3 botulinum toxin substrate 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0G2JUG6, A0A0G2K0X4
    Related
    ENSRNOP00000064762.4, ENSRNOT00000073886.4
    Conserved Domains (1) summary
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    106501133..106503569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269875.1 → XP_063125945.1  ras-related C3 botulinum toxin substrate 3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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