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Elovl5 ELOVL fatty acid elongase 5 [ Mus musculus (house mouse) ]

Gene ID: 68801, updated on 8-Feb-2024

Summary

Official Symbol
Elovl5provided by MGI
Official Full Name
ELOVL fatty acid elongase 5provided by MGI
Primary source
MGI:MGI:1916051
See related
Ensembl:ENSMUSG00000032349 AllianceGenome:MGI:1916051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HELO1; 1110059L23Rik
Summary
Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process; positive regulation of fatty acid biosynthetic process; and sphingolipid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in dendritic tree; endoplasmic reticulum; and neuronal cell body. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 38. Orthologous to human ELOVL5 (ELOVL fatty acid elongase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 103.9), adrenal adult (RPKM 79.4) and 25 other tissues See more
Orthologs
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Genomic context

See Elovl5 in Genome Data Viewer
Location:
9 E1; 9 43.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (77824647..77891801)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (77917365..77984519)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3846 Neighboring gene glutamate-cysteine ligase, catalytic subunit Neighboring gene predicted gene, 34654 Neighboring gene STARR-seq mESC enhancer starr_24706 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77758381-77758682 Neighboring gene STARR-positive B cell enhancer ABC_E6772 Neighboring gene STARR-positive B cell enhancer ABC_E2906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77766361-77766544 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77778672-77778973 Neighboring gene predicted gene, 34771 Neighboring gene predicted gene, 34829 Neighboring gene predicted gene, 39375 Neighboring gene predicted gene, 23609

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid elongase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic tree ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
very long chain fatty acid elongase 5
Names
3-keto acyl-CoA synthase Elovl5
ELOVL FA elongase 5
ELOVL family member 5, elongation of long chain fatty acids
elongation of very long chain fatty acids protein 5
fatty acid elongase 1
homolog of yeast long chain polyunsaturated fatty acid elongation enzyme
very long chain 3-ketoacyl-CoA synthase 5
very long chain 3-oxoacyl-CoA synthase 5
NP_599016.2
XP_006511463.1
XP_011241109.2
XP_030100414.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134255.3NP_599016.2  very long chain fatty acid elongase 5

    See identical proteins and their annotated locations for NP_599016.2

    Status: VALIDATED

    Source sequence(s)
    AK045274, AK162451, CF748582
    Consensus CDS
    CCDS23355.1
    UniProtKB/Swiss-Prot
    Q8BHI7, Q8BLG6, Q8BUE3, Q8R5D3
    UniProtKB/TrEMBL
    X2EXE4
    Related
    ENSMUSP00000034904.8, ENSMUST00000034904.14
    Conserved Domains (1) summary
    pfam01151
    Location:27261
    ELO; GNS1/SUR4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    77824647..77891801
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244554.2XP_030100414.1  very long chain fatty acid elongase 5 isoform X1

    UniProtKB/TrEMBL
    X2EXE4
    Conserved Domains (1) summary
    pfam01151
    Location:68302
    ELO; GNS1/SUR4 family
  2. XM_011242807.2XP_011241109.2  very long chain fatty acid elongase 5 isoform X3

    Conserved Domains (1) summary
    pfam01151
    Location:68265
    ELO; GNS1/SUR4 family
  3. XM_006511400.1XP_006511463.1  very long chain fatty acid elongase 5 isoform X2

    See identical proteins and their annotated locations for XP_006511463.1

    UniProtKB/Swiss-Prot
    Q8BHI7, Q8BLG6, Q8BUE3, Q8R5D3
    UniProtKB/TrEMBL
    X2EXE4
    Conserved Domains (1) summary
    pfam01151
    Location:27261
    ELO; GNS1/SUR4 family