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TACR1 tachykinin receptor 1 [ Homo sapiens (human) ]

Gene ID: 6869, updated on 13-Mar-2020

Summary

Official Symbol
TACR1provided by HGNC
Official Full Name
tachykinin receptor 1provided by HGNC
Primary source
HGNC:HGNC:11526
See related
Ensembl:ENSG00000115353 MIM:162323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPR; NK1R; NKIR; TAC1R
Summary
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
Expression
Broad expression in skin (RPKM 1.8), endometrium (RPKM 1.4) and 17 other tissues See more
Orthologs

Genomic context

See TACR1 in Genome Data Viewer
Location:
2p12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (75046463..75199520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75273590..75426645, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374809 Neighboring gene long intergenic non-protein coding RNA 1293 Neighboring gene DNA polymerase epsilon 4, accessory subunit Neighboring gene microRNA 5000 Neighboring gene uncharacterized LOC105374811 Neighboring gene uncharacterized LOC105374811 Neighboring gene uncharacterized LOC107985900 Neighboring gene uncharacterized LOC105374810

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
NHGRI GWA Catalog
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
substance P receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
substance P receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
tachykinin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
sperm head IDA
Inferred from Direct Assay
more info
PubMed 
sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm midpiece IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
substance-P receptor
Names
NK-1 receptor
NK-1R
tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029522.1 RefSeqGene

    Range
    5000..158056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001058.4NP_001049.1  substance-P receptor isoform long

    See identical proteins and their annotated locations for NP_001049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (long) represents the longer and predominant transcript and it encodes the longer protein (isoform long).
    Source sequence(s)
    AC007400, AC007681, AW206679, DB203452, M74290
    Consensus CDS
    CCDS1958.1
    UniProtKB/Swiss-Prot
    P25103
    Related
    ENSP00000303522.4, ENST00000305249.10
    Conserved Domains (1) summary
    cd16002
    Location:33316
    7tmA_NK1R; neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_015727.3NP_056542.1  substance-P receptor isoform short

    See identical proteins and their annotated locations for NP_056542.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (short) uses a different splice site in the 3' coding region, compared to variant long. The resulting protein (isoform short) has a shorter and distinct C-terminus when compared to the long isoform.
    Source sequence(s)
    AC007400, AC007681, DB203452, M74290, M84426
    Consensus CDS
    CCDS46345.1
    UniProtKB/Swiss-Prot
    P25103
    Related
    ENSP00000386448.3, ENST00000409848.3
    Conserved Domains (2) summary
    cd14964
    Location:3559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33311
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    75046463..75199520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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