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SYT5 synaptotagmin 5 [ Homo sapiens (human) ]

Gene ID: 6861, updated on 17-Jun-2019

Summary

Official Symbol
SYT5provided by HGNC
Official Full Name
synaptotagmin 5provided by HGNC
Primary source
HGNC:HGNC:11513
See related
Ensembl:ENSG00000129990 MIM:600782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in brain (RPKM 20.3) and adrenal (RPKM 2.1) See more
Orthologs

Genomic context

See SYT5 in Genome Data Viewer
Location:
19q13.42; 11p
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55171196..55180441, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55682571..55691809, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene troponin I3, cardiac type Neighboring gene uncharacterized LOC101930593 Neighboring gene dynein axonemal assembly factor 3 Neighboring gene protein tyrosine phosphatase receptor type H Neighboring gene transmembrane protein 86B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
    Regulation of insulin secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal neuron projection IEA
Inferred from Electronic Annotation
more info
 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptotagmin-5
Names
synaptotagmin V
sytV

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297774.2NP_001284703.1  synaptotagmin-5 isoform 2

    See identical proteins and their annotated locations for NP_001284703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple coding region differences, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010327, AK295337, BM311004
    Consensus CDS
    CCDS74455.1
    UniProtKB/Swiss-Prot
    O00445
    Related
    ENSP00000465576.1, ENST00000590851.5
    Conserved Domains (2) summary
    cd08385
    Location:106228
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:236370
    C2; C2 domain
  2. NM_003180.3NP_003171.2  synaptotagmin-5 isoform 1

    See identical proteins and their annotated locations for NP_003171.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010327, BC046157, BQ417474, DA529870
    Consensus CDS
    CCDS12919.1
    UniProtKB/Swiss-Prot
    O00445
    UniProtKB/TrEMBL
    A0A024R4N8
    Related
    ENSP00000346265.2, ENST00000354308.8
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:240374
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55171196..55180441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723340.3XP_006723403.1  synaptotagmin-5 isoform X2

    See identical proteins and their annotated locations for XP_006723403.1

    UniProtKB/TrEMBL
    Q4FD32
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:239373
    C2; C2 domain
  2. XM_017027175.1XP_016882664.1  synaptotagmin-5 isoform X1

    UniProtKB/Swiss-Prot
    O00445
    UniProtKB/TrEMBL
    A0A024R4N8
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:240374
    C2; C2 domain
  3. XM_024451668.1XP_024307436.1  synaptotagmin-5 isoform X2

    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:239373
    C2; C2 domain
  4. XM_006723339.3XP_006723402.1  synaptotagmin-5 isoform X1

    See identical proteins and their annotated locations for XP_006723402.1

    UniProtKB/Swiss-Prot
    O00445
    UniProtKB/TrEMBL
    A0A024R4N8
    Related
    ENSP00000442896.1, ENST00000537500.5
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:240374
    C2; C2 domain
  5. XM_006723341.3XP_006723404.1  synaptotagmin-5 isoform X3

    Conserved Domains (2) summary
    cd08385
    Location:106228
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:237371
    C2; C2 domain
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