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SYT5 synaptotagmin 5 [ Homo sapiens (human) ]

Gene ID: 6861, updated on 8-Dec-2022

Summary

Official Symbol
SYT5provided by HGNC
Official Full Name
synaptotagmin 5provided by HGNC
Primary source
HGNC:HGNC:11513
See related
Ensembl:ENSG00000129990 MIM:600782; AllianceGenome:HGNC:11513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
Expression
Biased expression in brain (RPKM 20.3) and adrenal (RPKM 2.1) See more
Orthologs
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Genomic context

See SYT5 in Genome Data Viewer
Location:
19q13.42; 11p
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55171196..55180289, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58265259..58274351, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55682564..55691657, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DNAAF3 antisense RNA 1 Neighboring gene dynein axonemal assembly factor 3 Neighboring gene small nucleolar RNA U13 Neighboring gene protein tyrosine phosphatase receptor type H Neighboring gene uncharacterized LOC124904771

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in proximal neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
synaptotagmin-5
Names
synaptotagmin V
sytV

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297774.2NP_001284703.1  synaptotagmin-5 isoform 2

    See identical proteins and their annotated locations for NP_001284703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple coding region differences, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010327, AK295337, BM311004
    Consensus CDS
    CCDS74455.1
    UniProtKB/Swiss-Prot
    O00445
    Related
    ENSP00000465576.1, ENST00000590851.5
    Conserved Domains (2) summary
    cd08385
    Location:106228
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:236370
    C2; C2 domain
  2. NM_003180.3NP_003171.2  synaptotagmin-5 isoform 1

    See identical proteins and their annotated locations for NP_003171.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010327, BC046157, BQ417474, DA529870
    Consensus CDS
    CCDS12919.1
    UniProtKB/Swiss-Prot
    O00445, Q86X72
    UniProtKB/TrEMBL
    A0A024R4N8
    Related
    ENSP00000346265.2, ENST00000354308.8
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:240374
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55171196..55180289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439257.1XP_047295213.1  synaptotagmin-5 isoform X2

    UniProtKB/TrEMBL
    Q4FD32
  2. XM_017027175.2XP_016882664.1  synaptotagmin-5 isoform X1

    UniProtKB/Swiss-Prot
    O00445, Q86X72
    UniProtKB/TrEMBL
    A0A024R4N8
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:240374
    C2; C2 domain
  3. XM_047439256.1XP_047295212.1  synaptotagmin-5 isoform X1

    UniProtKB/Swiss-Prot
    Q86X72
    UniProtKB/TrEMBL
    A0A024R4N8
  4. XM_006723339.4XP_006723402.1  synaptotagmin-5 isoform X1

    See identical proteins and their annotated locations for XP_006723402.1

    UniProtKB/Swiss-Prot
    O00445, Q86X72
    UniProtKB/TrEMBL
    A0A024R4N8
    Related
    ENSP00000442896.1, ENST00000537500.5
    Conserved Domains (2) summary
    cd08385
    Location:109231
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:240374
    C2; C2 domain
  5. XM_006723341.4XP_006723404.1  synaptotagmin-5 isoform X3

    Conserved Domains (2) summary
    cd08385
    Location:106228
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cl14603
    Location:237371
    C2; C2 domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58265259..58274351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)