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Tbc1d10b TBC1 domain family, member 10b [ Mus musculus (house mouse) ]

Gene ID: 68449, updated on 14-May-2024


Official Symbol
Tbc1d10bprovided by MGI
Official Full Name
TBC1 domain family, member 10bprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000042492 AllianceGenome:MGI:1915699
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and retrograde transport, endosome to Golgi. Predicted to be located in plasma membrane. Orthologous to human TBC1D10B (TBC1 domain family member 10B). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in thymus adult (RPKM 22.9), ovary adult (RPKM 16.8) and 28 other tissues See more
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Genomic context

See Tbc1d10b in Genome Data Viewer
7 F3; 7 69.38 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126796631..126807640, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127197459..127208468, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134332123-134332276 Neighboring gene STARR-positive B cell enhancer ABC_E4977 Neighboring gene CD2 cytoplasmic tail binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene septin 1 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene zinc finger protein 553

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
TBC1 domain family member 10B
protein wz3-85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144522.5NP_653105.3  TBC1 domain family member 10B

    See identical proteins and their annotated locations for NP_653105.3

    Status: VALIDATED

    Source sequence(s)
    AC122537, AK047320
    Consensus CDS
    Q6GQW9, Q6PIZ5, Q8BHL3, Q91XR3
    ENSMUSP00000113307.2, ENSMUST00000120705.3
    Conserved Domains (2) summary
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PRK12323; DNA polymerase III subunit gamma/tau

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000073.7 Reference GRCm39 C57BL/6J

    126796631..126807640 complement
    GenBank, FASTA, Sequence Viewer (Graphics)